Clinical Application of Trans-Arterial Radioembolization in Hepatic Malignancies in Europe: First Results from the Prosp
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CLINICAL INVESTIGATION
INTERVENTIONAL ONCOLOGY
Clinical Application of Trans-Arterial Radioembolization in Hepatic Malignancies in Europe: First Results from the Prospective Multicentre Observational Study CIRSE Registry for SIR-Spheres Therapy (CIRT) Thomas Helmberger1 • Rita Golfieri2 • Maciej Pech3 • Thomas Pfammatter4 • Dirk Arnold5 • Roberto Cianni6 • Geert Maleux7 • Graham Munneke8 • Olivier Pellerin9 • Bora Peynircioglu10 Bruno Sangro11 • Niklaus Schaefer12 • Niels de Jong13 • Jose´ Ignacio Bilbao14 • On behalf of the CIRT Steering Committee • On behalf of the CIRT Principal Investigators
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Received: 1 July 2020 / Accepted: 2 September 2020 The Author(s) 2020
Abstract Purpose To address the lack of prospective data on the real-life clinical application of trans-arterial radioembolization (TARE) in Europe, the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) initiated the prospective observational study CIRSE Registry for SIR-Spheres Therapy (CIRT).
Materials and Methods Patients were enrolled from 1 January 2015 till 31 December 2017. Eligible patients were adult patients treated with TARE with Y90 resin microspheres for primary or metastatic liver tumours. Patients were followed up for 24 months after treatment, whereas data on the clinical context of TARE, overall survival (OS) and safety were collected. Results Totally, 1027 patients were analysed. 68.2% of the intention of treatment was palliative. Up to half of the patients received systemic therapy and/or locoregional treatments prior to TARE (53.1%; 38.3%). Median overall
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00270-020-02642-y) contains supplementary material, which is available to authorized users. & Niels de Jong [email protected] 1
Department of Radiology, Neuroradiology and MinimalInvasive Therapy, Klinikum Bogenhausen, Englschalkinger Str. 77, 81925 Munich, Germany
2
Radiology Unit, Department of Experimental, Diagnostic and Speciality Medicine, Sant’Orsola Hospital, University of Bologna, Via Bagni di Mario 15, 40136 Bologna, Italy
3
Department of Radiology and Nuclear Medicine, University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
7
Radiology, Universitair Ziekenhuis Leuven, Herestraat 49, 3000 Leuven, Belgium
8
Interventional Oncology, University College London Hospitals NHS Foundation Trust, 250 Euston Road, NW1 2PG London, UK
9
Interventional Radiology Department, Hoˆpital Europe´en Georges Pompidou, 20 rue Leblanc, 75015 Paris, France
10
Department of Radiology, School of Medicine, Hacettepe University, Sihhiye Campus, 06100 Ankara, Turkey
11
Liver Unit, Clı´nica Universidad de Navarra, IDISNA and CIBEREHD, Avda. Pio XII 36, 31008 Pamplona, Spain
4
Institut fu¨r Diagnostische und Interventionelle Radiologie, Universita¨tsspital Zu¨rich, Ra¨mistrasse 100, 8091 Zu¨rich, Switzerland
12
Service de me´decine nucle´aire et imagerie mole´culaire, Inselspital Hospital Lausanne, Rue du Bugnon 46, 1011 Lausanne, Switzerland
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