Intra-hepatic Abscopal Effect Following Radioembolization of Hepatic Metastases
- PDF / 944,466 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 52 Downloads / 175 Views
CLINICAL INVESTIGATION
INTERVENTIONAL ONCOLOGY
Intra-hepatic Abscopal Effect Following Radioembolization of Hepatic Metastases Maciej Powerski1 • Ralph Drewes1 Alexey Surov1 • Maciej Pech1,2
•
Jazan Omari1 • Borna Relja1
•
Received: 26 March 2020 / Accepted: 2 August 2020 Ó The Author(s) 2020
Abstract Purpose To search for abscopal effects (AE) distant to the site of radiation after sequential Yittrium-90 (Y-90) radioembolization (RE) of liver malignancies. Methods and Materials In this retrospective analysis, all patients treated by RE between 2007 and 2018 (n = 907) were screened for the following setting/conditions: sequential RE of left and right liver lobe in two sessions, liver-specific MRI (MRI1) acquired max. 10 days before or after first RE (RE1), liver-specific MRI (MRI2) acquired with a minimum time interval of 20 days after MRI1, but before second RE (RE2). No systemic tumor therapies between MRI1 and MRI2. No patients with liver cirrhosis. Metastases [ 5 mm in untreated liver lobes were Maciej Powerski and Ralph Drewes contributed equally to this work. & Ralph Drewes [email protected] Maciej Powerski [email protected]
compared in MRI1 and MRI2 and rated as follows: same size or larger in MRI2 = no abscopal effect (NAE); [ 30% shrinkage without Y-90 contamination in SPECT/ CT = abscopal effect (AE). Results Ninety six of 907 patients met aforementioned criteria. Median time-frame between RE1 and MRI2 was 34 (20–64) days. These 96 cases had 765 metastases which were evaluable (median 5(1–40) metastases per patient). Four patients could be identified with at least one shrinking metastasis of the untreated site: one patient with breast cancer (3 metastases: 0 NAE; 3 AE), one patient with prostate cancer (6 metastases: 3 NAE; 3 metastases [ 30% shrinkage but possible Y-90 contamination) and two patients with shrinkage of one metastasis each but less than 30%. Conclusion Our retrospective study documents AE after RE of liver tumors in 1 out of 96 cases, 3 other cases remain unclear. Keywords Abscopal effect Radioembolization SIRT
Jazan Omari [email protected] Borna Relja [email protected] Alexey Surov [email protected] Maciej Pech [email protected] 1
Department of Radiology and Nuclear Medicine, Otto-VonGuericke University, Leipziger Str. 44, 39120 Magdeburg, Germany
2
2nd Department of Radiology, Medical University of Gdansk, Mariana Smoluchowskiego 17, 80-214, Gdansk, Poland
Introduction Radiotherapy (RT) represents one cornerstone of the established oncological treatment regimens. Over 60% of all cancer patients receive some form of RT during their cancer treatment [1]. The general dogmatic consensus established that the efficacy of RT is exclusively limited to the induction of cancer cell death and the eradication of clonogenic survival. However, several case reports, sporadically published over the last decades, documented the
123
M. Powerski et al.: Intra-hepatic Abscopal Effect Following Radioembolization...
phenomenon of tumor regression
Data Loading...
