Clinical Applications of Botulinum Neurotoxin
Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection
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Series Editors Richard M. Kostrzewa East Tennessee State University, Kostrzewa, USA Trevor Archer Department of Psychology, Göteborg University, Göteborg, Sweden
For further volumes: http://www.springer.com/series/8791
Keith A. Foster Editor
Clinical Applications of Botulinum Neurotoxin
2123
Editor Keith A. Foster Syntaxin Ltd Units 4–10 The Quadrant Barton Lane Abingdon OX14 3YS Oxfordshire United Kingdom
ISBN 978-1-4939-0260-6 ISBN 978-1-4939-0261-3 (eBook) DOI 10.1007/978-1-4939-0261-3 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2014930101 © Springer Science+Business Media New York 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
1
Overview and History of Botulinum Neurotoxin Clinical Exploitation Keith A. Foster
2
Botulinum Toxin as a Clinical Product: Manufacture and Pharmacology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Andy Pickett
1
7
3
Clinical Use of Botulinum Neurotoxin: Neuromuscular Disorders . . . Arianna Guidubaldi, Anna Rita Bentivoglio and Alberto Albanese
51
4
Clinical Use of Botulinum Neurotoxin: Autonomic Conditions . . . . . . . Dirk Dressler
95
5
Clinical Use of Botulinum Neurotoxin: Urogenital Disorders Including Overactiv
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