Clinical Applications of Immunomics
Immunomics Reviews An Official Publication of the International Immunomics Society Series Editors: Vladimir Brusic, Dana-Farber Cancer Institute, Boston, Massachusetts Andras Falus, Semmelweis University, Budapest, Hungary Editorial Board: Anne S. De Groo
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Immunonomics Reviews An Official Publication of the International Immunomics Society Series Editors: Vladimir Brusic, Dana-Farber Cancer Institute, Boston, Massachusetts Andras Falus, Semmelweis University, Budapest, Hungary Editorial Board: Anne S. De Groot, Brown University, Providence, Rhode Island Darren Flower, Edward Jenner Institute for Vaccine Research, Berkshire, UK Christian Schonbach, Nanyang Technological University, Singapore Shoba Ranganathan, Macquarie University, Australia Marie-Paule Lefranc Universite Montpellier II, Montpellier, France
This peer-reviewed book series offers insight on immunology for 21st century. The technological revolution has borne advances in high-throughput instrumentation and information technology, initiating a renaissance for biomathematics, and biostatistics. Cross-fertilization between genomics and immunology has led to a new field called immunomics, transforming the way in which theoretical, clinical and applied immunology are practiced. Immunomics Reviews will cover integrative approaches and applications to the theory and practice of immunology and explore synergistic effects resulting from a combination of technological advances and the latest analytical tools with the traditional fields of basic and clinical immunology.
Andras Falus Editor
Clinical Applications of Immunomics
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Editor Andras Falus Semmelweis University Budapest, Hungary [email protected]
ISBN: 978-0-387-79207-1 e-ISBN: 978-0-387-79208-8 DOI: 10.1007/978-0-387-79208-8 Library of Congress Control Number: 2008934033 # Springer ScienceþBusiness Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer ScienceþBusiness Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper springer.com
Contents
Integrative Systems Approaches to Study Innate Immunity . . . . . . . . . . . . Timothy Ravasi
1
Immunomics: At the Forefront of Innate Immunity Research . . . . . . . . . . Hongtao Guan, Steven K Dower, and Endre Kiss-Toth
15
Epitope-Based Immun
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