Clinical feasibility and impact of fully automated multiparametric PET imaging using direct Patlak reconstruction: evalu
- PDF / 9,340,118 Bytes
- 14 Pages / 595.276 x 790.866 pts Page_size
- 20 Downloads / 168 Views
ORIGINAL ARTICLE
Clinical feasibility and impact of fully automated multiparametric PET imaging using direct Patlak reconstruction: evaluation of 103 dynamic whole-body 18F-FDG PET/CT scans André H. Dias 1
&
Mette F. Pedersen 1 & Helle Danielsen 1 & Ole L. Munk 1,2
&
Lars C. Gormsen 1,2
Received: 22 May 2020 / Accepted: 18 August 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Functional imaging by standard whole-body (WB) 18F-flurodeoxyglucose (FDG) positron emission tomography (PET) is an integrated part of disease diagnostics. Recently, a clinical dynamic whole-body (D-WB) FDG PET/CT scanning protocols has been developed allowing for quantitative imaging of tissue metabolic rate of FDG (MRFDG). It was the purpose of this retrospective study to evaluate whether MRFDG imaging is feasible in a clinical setting and whether it improves lesion detectability. Methods One hundred nine patients representing a broad range of referral indications for FDG PET/CT were invited to undergo a D-WB FDG PET/CT scan. Two sets of images were produced: parametric images and standard static SUV images. Both sets of images were reviewed visually, and 310 individual lesions were quantitatively analysed using the target-to-background (TBR) and contrast-to-noise (CNR) metrics. Results One hundred three out of 109 patients completed the D-WB FDG PET/CT scan. There was no difference in the number of pathological lesions identified visually on the MRFDG and the SUV images, whereas MRFDG images yielded 4 fewer false positives than the SUV images. Quantitatively, MRFDG TBR was significantly higher than SUV TBR in 299/310 lesions, and better MRFDG CNR was found to facilitate the challenging reading of lesions with low SUV TBR. Conclusion D-WB FDG PET/CT is feasible in a clinical setting and produces MRFDG images of good visual quality and superior lesion contrast. In addition, MRFDG images complement the standard SUV images providing better quantification and enhanced image reading. However, although MRFDG also reduced the number of false-positive findings, no additional malignant lesions were identified. The technique therefore appears to be best suited for select patient groups or possibly treatment response evaluation. Keywords Dynamic whole-body PET . FDG . Parametric imaging . Patlak . Oncology . Clinical
Introduction Ole L. Munk and Lars C. Gormsen contributed equally to this work. This article is part of the Topical Collection on Oncology - General Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00259-020-05007-2) contains supplementary material, which is available to authorized users. * Lars C. Gormsen [email protected] 1
Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, DK-8200 Aarhus N, Denmark
2
Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
Functional imaging by 18F-flurodeoxyglucose (FDG) positron emission tomography (PET) is an integrated part of
Data Loading...
