Feasibility and kinetic characteristics of 68 Ga-NOTA-RGD PET for in vivo atherosclerosis imaging
- PDF / 682,727 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 40 Downloads / 196 Views
ORIGINAL ARTICLE
Feasibility and kinetic characteristics of for in vivo atherosclerosis imaging Jin Chul Paeng • Yun-Sang Lee • Jae Sung Lee • Jae Min Jeong • Ki-Bong Kim • June-Key Chung Dong Soo Lee
68
Ga-NOTA-RGD PET
•
Received: 22 April 2013 / Accepted: 9 July 2013 Ó The Japanese Society of Nuclear Medicine 2013
Abstract Objective In this study, the feasibility and kinetic characteristics of the 68Ga-NOTA-RGD, a recently developed RGD peptide agent, were investigated for atherosclerosis imaging in comparison with 18FDG. Methods ApoE-/- mice were fed a high-fat diet for more than 20 weeks. To evaluate the feasibility, tissue uptakes of 68 Ga-NOTA-RGD and 18FDG in the major organs were measured and compared between ApoE-/- and control mice. Animal PET imaging was also performed and relative uptake values in the thoracic aorta were compared between ApoE-/and control mice. In humans, the kinetic characteristics and feasibility of 68Ga-NOTA-RGD PET were assessed in 4 patients with known coronary artery disease. Results In the tissue uptake study, the thoracic aorta showed higher uptake in ApoE-/- than in control mice with both 68Ga-NOTA-RGD and 18FDG (P \ 0.001). On PET scans, the relative uptake values of the thoracic aorta were significantly higher in ApoE-/- with both 68Ga-NOTARGD (P = 0.024) and 18FDG (P = 0.038). In human PET, J. C. Paeng Y.-S. Lee J. S. Lee J. M. Jeong J.-K. Chung D. S. Lee (&) Department of Nuclear Medicine, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, Korea e-mail: [email protected] J. C. Paeng e-mail: [email protected] K.-B. Kim Department of Thoracic and Cardiovascular Surgery, Seoul National University College of Medicine, Seoul, Korea D. S. Lee Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, Korea
the appropriateness of reversible binding model and Logan plotting was clearly demonstrated. The aorta-to-jugular ratios were measured up to 1.25 and showed a tendency to correlate with the serum high-sensitivity C-reactive protein level (r = 0.899, P = 0.102). Conclusions 68Ga-NOTA-RGD has potential as an in vivo atherosclerosis imaging agent. However, the lower imaging contrast and sensitivity of 68Ga-NOTA-RGD PET compared with 18FDG PET may be a limitation for clinical application. Keywords Atherosclerosis Vulnerable plaque Molecular imaging 68Ga-NOTA-RGD PET
Introduction Coronary and cerebrovascular diseases resulting from atherosclerosis are usually included among the three most common causes of death in worldwide surveys. Atherosclerotic plaques with vascular narrowing can be morphologically visualized by conventional coronary angiography (CAG), computed tomography (CT), and magnetic resonance imaging (MRI); however, the simple presence of atherosclerosis or vascular narrowing has limited clinical significance. In fact, in a considerable proportion of myocardial infarcts, the culprit coronary lesions do not show critical narrowing [1]. Additionally, in up to 62 % of male and
Data Loading...
