Clinical features and outcomes of seven patients with COVID-19 in a family cluster
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CASE REPORT
Open Access
Clinical features and outcomes of seven patients with COVID-19 in a family cluster Yiling Zhang1†, Cheng Zhang1†, Ying Hu1, Hongmei Yao1, Xianchun Zeng1, Changrong Hu2, Li Zhao1, Xiangyan Zhang1* and Xianwei Ye1*
Abstract Background: The family cluster is one of most important modes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission throughout China, and more details are needed about how family clusters cause the spread of coronavirus disease 2019 (COVID-19). Case presentation: We retrospectively reviewed 7 confirmed cases from one family cluster. Both clinical features and laboratory examination results were described. Patient 1 had been in close contact with someone who was later confirmed to have COVID-19 in Wuhan City before he returned back to his hometown. He had dinner with 6 other members in his family. All the persons developed COVID-19 successively except for one older woman who neither had dinner with them nor shared a sleeping room with her husband. Six patients had mild or moderate COVID-19 but one older man with underlying diseases progressed into the severe type. After general and symptomatic treatments, all the patients recovered. Conclusions: In a family cluster, having dinner together may be an important mode for the transmission of SARSCoV-2. In this setting, most cases are mild with a favorable prognosis, while elderly patients with underlying diseases may progress into the severe type. For someone who has close contact with a confirmed case, 14-day isolation is necessary to contain virus transmission. Keywords: Clinical features, SARS-CoV-2, COVID-19,family cluster, Case report
Background In December 2019, an outbreak of a novel coronavirus disease was reported in Wuhan, China. The virus was subsequently renamed SARS-CoV-2, which caused COVID-19. At present, we know that SARS-CoV-2 infects ciliated bronchial epithelial cells and type-II pneumocytes through angiotensin-converting enzyme 2 (ACE2) as receptor [1, 2]. Its infection leads to higher mortality [3–6], which is a serious threat to global public health. The sustained human-to-human transmission of * Correspondence: [email protected]; [email protected] † Yiling Zhang and Cheng Zhang contributed equally to this work. 1 Department of Respiratory and Critical Care Medicine, Guizhou Provincial People’s Hospital, State Key Laboratory of Diagnosis and Treatment of Lung Immune Diseases, Guiyang 550002, China Full list of author information is available at the end of the article
SARS-CoV-2 in China is mostly caused by family clusters and intimate contact, but the details of the former transmission mode have not yet been fully investigated. Therefore, we introduce a family cluster of 7 patients with COVID-19 in Liupanshui City, Guizhou Province, and analyze their exposure to sources of transmission, symptoms, coexisting disorders, disease severity, radiologic findings, clinical characteristics, laboratory findings and treatment. Our findings will facilitate the understanding of the clinical featu
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