Clinical features of gingivostomatitis due to primary infection of herpes simplex virus in children
- PDF / 516,037 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 95 Downloads / 201 Views
RESEARCH ARTICLE
Open Access
Clinical features of gingivostomatitis due to primary infection of herpes simplex virus in children Chen-Wei Huang1†, Chi-Hsien Hsieh1†, Ming-Ru Lin1,2 and Yhu-Chering Huang1,2*
Abstract Background: Primary herpetic gingivostomatitis (PHGS) in children, though usually self-limited, might mimic bacterial and enteroviral pharyngitis clinically. We conducted a study to define the clinical features of PHGS in children. Methods: Between January 2012 and December 2016, 282 inpatients aged less than 19 years with cell cultureconfirmed herpes simplex virus (HSV) infection in a medical center were identified from the virologic laboratory logbook. Clinical data were retrospectively collected. Results: Among the 282 inpatients, 185 cases were considered as PHGS and were included for analysis. Fever was present in 99.5%. The mean duration of fever was 5.11 days (±2.24) with the longest being 17 days. Common oral manifestations included oral ulcers (84.3%), which equally resided in the anterior and posterior part of the oral cavity (65.4% vs. 63.2%), gum swelling and/or bleeding (67.6%), and exudate coated tonsils (16.8%). Leukocytosis (WBC count > 15,000/uL3) was noted in 52 patients (28.1%) and a serum C-reactive protein level > 40 mg/L in 55 patients (29.7%). Fixty-five patients (35%) were diagnosed with PHGS on admission and were significantly more likely to have ulcers over the anterior oral cavity (76.1% vs. 26.7%) and gum swelling/bleeding (76.2% vs. 7.5%, p-value all < 0.001) on admission and were significantly less likely to receive antibiotic treatment (16.9 vs. 36.7%, p-value < 0.01) than others. Forty-six patients (25%) undiagnosed as PHGS on discharge were significantly more likely to have exudate coated on the tonsils, to receive antibiotic treatment and significantly less likely to have gum swelling/bleeding and oral ulcers (all p-values < 0.01). Conclusions: Meticulously identifying specific oral manifestations of gum swelling/bleeding and ulcers over the anterior oral cavity in children can help making the diagnosis of PHGS earlier and subsequently reduce unnecessary prescription of antibiotics. Keywords: Herpes simplex virus, Primary herpetic gingivostomatitis, Children, Clinical manifestation
* Correspondence: [email protected] † Chen-Wei Huang and Chi-Hsien Hsieh contributed equally to this work. 1 Department of Medicine, Chang Gung University College of Medicine, Taoyuan, Taiwan 2 Department of Pediatrics, Chang Gung Memorial Hospital, No.5, Fu-Hsin Street, Kweishan, 333 Taoyuan, Taiwan © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence,
Data Loading...
