Clinical features of Japanese patients with exacerbations of chronic obstructive pulmonary disease
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RESEARCH ARTICLE
Open Access
Clinical features of Japanese patients with exacerbations of chronic obstructive pulmonary disease Hiroki Tashiro1, Yuki Kurihara1, Koichiro Takahashi1* , Hironori Sadamatsu1, Tetsuro Haraguchi1, Ryo Tajiri2, Ayako Takamori2, Shinya Kimura1 and Naoko Sueoka‑Aragane1
Abstract Background: Exacerbations are critical events in chronic pulmonary obstructive disease (COPD). The frequency of COPD exacerbations is associated with the prognosis, including mortality, but no useful biomarker has been established. Methods: The present retrospective study investigated 481 COPD patients. Clinical features in the stable period were compared between patients who experienced severe exacerbation (n = 88, 18.3%) and those who never experienced severe exacerbation (n = 393, 81.7%). In the patients who experienced exacerbations, clinical features were also com‑ pared between frequent exacerbators (exacerbation rate ≥ 2 times/year, n = 27, 30.7%) and infrequent exacerbators (1 time/year, n = 61, 69.3%). Results: Compared to COPD patients who never experienced exacerbations, body mass index (BMI), serum albumin, and pulmonary functions were significantly lower, and the cardiovascular disease comorbidity rate, COPD assessment test score, modified Medical Research Council dyspnea scale, and use of long-term oxygen therapy, long-acting β2 adrenergic agonist therapy, inhaled corticosteroid therapy, and macrolide therapy were significantly higher in COPD patients with exacerbations (all p
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