Clinical profile, viral load, management and outcome of neonates born to COVID 19 positive mothers: a tertiary care cent
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ORIGINAL ARTICLE
Clinical profile, viral load, management and outcome of neonates born to COVID 19 positive mothers: a tertiary care centre experience from India Pratima Anand 1 & Anita Yadav 1 & Pradeep Debata 1
&
Sumitra Bachani 2 & Nitesh Gupta 3 & Rani Gera 1
Received: 17 July 2020 / Revised: 27 August 2020 / Accepted: 31 August 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Despite rapidly evolving knowledge about COVID 19 infection, routes of perinatal COVID 19 transmission and viral load in mother neonate dyad remain uncertain. Data were analysed to describe the clinicodemographic profile and viral load in neonates born to COVID 19 positive mothers. Of 2947 deliveries, 69 mothers were COVID 19 positive (2.3%), with 1 abortion, 2 macerated stillbirths and 2 fresh stillbirths as pregnancy outcomes. Of 65 tested neonates, 10.7% (7) were confirmed COVID 19 positive by RTPCR (reverse transcriptase-polymerase chain reaction). Viral load (cycle threshold, Ct of E, RDRp) in neonates was comparable with the Ct reported from adults; however, neonates had milder clinical manifestations. All 7 neonates who tested positive for COVID 19 were subsequently discharged. Six of the 7 neonates were asymptomatic and 1 neonate needed respiratory support (indication being prematurity) which resolved after 48 h. Maternal and neonatal comparison of Ct of E and RdRp gene was statistically non-significant (25.97 vs 19.68, p = 0.34 and 26.5 vs 25.0, p = 0.84). Viral loads of mothers with COVID 19 positive neonates compared with mothers with COVID 19 negative neonates for E and RdRp gene were also statistically non-significant (25 vs 27.19, p = 0.63 and 19.6 vs 27.6, p = 0.08). The majority (93%) of neonates tested later than 48 h (roomed in with mother and breastfed) tested negative. Conclusion: The study supports milder manifestation in COVID 19 positive neonates. Risk of transmission from COVID 19 positive mother to neonate by rooming-in and breastfeeding is low. In this study on a limited number of neonates, maternal viral load was not found to be associated with the positivity status or severity of the illness of neonate.
Communicated by Daniele De Luca Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00431-020-03800-7) contains supplementary material, which is available to authorized users. * Pradeep Debata [email protected] Pratima Anand [email protected] Anita Yadav [email protected]
Rani Gera [email protected]
1
Department of Paediatrics, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi 110023, India
2
Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India
3
Department of Respiratory Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India
Sumitra Bachani [email protected] Nitesh Gupta [email protected]
Eur J Pediatr
What is Known: • Neonates born to COVID 19 positive mothers are at risk of COVID 19 infection. W
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