Two seriously ill neonates born to mothers with COVID-19 pneumonia- a case report
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CASE REPORT
Open Access
Two seriously ill neonates born to mothers with COVID-19 pneumonia- a case report Setareh Sagheb1, Ameneh Lamsehchi1, Mohamadreza Jafary2, Reza Atef-Yekta3 and Kourosh Sadeghi4*
Abstract Background: Coronavirus disease 2019 (COVID-19), a highly contagious viral disease has spread from Wuhan, Hubei Province, China to all over the world from its first recognition on December 2019. To date, only a few neonatal early-onset sepsis by SARS-COV-2 has been reported worldwide. Case presentation: In this report, we present two seriously ill neonates who were born from mothers with stablished COVID-19 pneumonia. Laboratory tests showed lymphopenia with high LDH and hypocalcemia right after the birth. They had fever for days without responding to antibiotics and despite ruling out other potential causes. Both patients had positive RTPCR for SARS-COV-2 in the second round of testing but the first assay tested was negative. Hydroxychloroquine was used to treat both patients; the first patient was treated with it over a period of 14 days before showing signs of improvement. The second patient responded to the treatment over a period of 5 days. Conclusion: Although based on the available evidences, vertical transmission of COVID-19 is less likely, many aspects of pathogenesis and transmission of this novel virus are still unclear. Therefore we cannot rule out the vertical transmission totally. Further investigations are warranted to determine the exact mechanisms and routes of transmission. Keywords: Neonate, Vertical transmission, COVID-19, SARS-COV-2, Case report
Background Since December 2019, the coronavirus disease (COVID19), which is a highly contagious virus, has been rapidly spreading worldwide. Accordingly, it was firstly appeared in Wuhan, Hubei Province, China [1]. Coronavirus is an RNA virus, which can cause a wide spectrum of clinical manifestations in human from a common cold to severe acute respiratory syndrome (SARS) known as the SARSassociated coronavirus [2]. It was reported that Severe Acute Respiratory Syndrome coronavirus 2 (SARS-COV2) similar to SARS-COV and Middle East Respiratory Syndrome Coronavirus (MERS-COV), does not have vertical transmission from mother diagnosed with COVID-19 infection to her fetus [3, 4]. However, reports of 3 neonates * Correspondence: [email protected] 4 Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Full list of author information is available at the end of the article
with early-onset COVID-19 infection in China pointed out that not much is understood on intrauterine transmission, so further investigations are required. To date, few neonates infected by COVID-19 have been reported [5]. In the following sections, we presented two neonates with COVID-19 positive reverse transcription polymerase chain reaction (RT-PCR) assay in Iran. These two affected neonates’ parents provided us with a written consent to report on their neonates. This survey was approved by the Medical Ethics Committee of Tehran Universit
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