Clinical significance of preoperative CA19-9 and lymph node metastasis in intrahepatic cholangiocarcinoma
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ORIGINAL ARTICLE
Clinical significance of preoperative CA19‑9 and lymph node metastasis in intrahepatic cholangiocarcinoma Tadafumi Asaoka1,2 · Shogo Kobayashi1 · Takehiko Hanaki1 · Yoshifumi Iwagami1 · Yoshito Tomimaru1 · Hirofumi Akita1 · Takehiro Noda1 · Kunihito Gotoh1 · Yutaka Takeda1,3 · Masahiro Tanemura1,4 · Yuichiro Doki1 · Hidetoshi Eguchi1 Received: 25 December 2019 / Accepted: 6 March 2020 © Springer Nature Singapore Pte Ltd. 2020
Abstract Purpose This study aimed to identify prognostic factors for patients with ICC after a curative resection and clarify the appropriate indications for surgical resection and postoperative adjuvant chemotherapy. Methods This retrospective study included 81 patients who underwent curative resection for ICC between April 1995 and December 2014. Kaplan–Meier and Cox regression models were used to analyze the effects of clinicopathological features on overall and recurrence-free survival. Results The cumulative 5-year overall survival of 81 patients was 57.2%, and the 5-year recurrence-free survival was 24.0%. The multivariate analysis identified the lymph node status and preoperative CA19-9 levels as independent prognostic factors for overall survival. The 5-year overall survival rates were 79.9% and 38.7% in patients with normal and elevated CA19-9, respectively (p
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