Clinical Trials in Osteoporosis
The second revised and updated edition of Clinical Trials in Osteoporosis is a practical handbook on clinical trials in the growing field of osteoporosis. Topics covered include study design, technical issues, data collection, quality assurance, data anal
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Clinical Trials in Osteoporosis Second Edition
Edited by
Derek Pearson and
Colin G. Miller
Colin G. Miller, PhD, FICR Sr. Vice President Medical Affairs Bio-Imaging Technologies Inc. Newtown, PA USA
Derek Pearson, BSc, PhD Joint Service Manager Medical Physics & Clinical Engineering Department Nottingham University Hospitals NHS Trust Nottingham UK
British Library Cataloguing in Publication Data Clinical trials in osteoporosis - 2nd ed. 1. Osteoporosis - Chemotherapy - Research - Handbooks, manuals, etc. 2. Drugs - Testing Handbooks, manuals, etc. I. Pearson, Derek, 1954- II. Miller, Colin G., 1960616.7⬘16 Library of Congress Control Number: 2006931121 ISBN-10: 1-84628-389-2 2nd edition ISBN-13: 978-1-84628-389-5 2nd edition ISBN-10: 1-85233-229-8 1st edition
e-ISBN-10: 1-84628-587-9 2nd edition e-ISBN-13: 978-1-84628-587-5 2nd edition
Printed on acid-free paper © Springer-Verlag London Limited 2007 First published 2002 Second edition 2007 Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the Copyright, Designs and Patents Act 1988, this publication may only be reproduced, stored or transmitted, in any form or by any means, with the prior permission in writing of the publishers, or in the case of reprographic reproduction in accordance with the terms of licences issued by the Copyright Licensing Agency. Enquiries concerning reproduction outside those terms should be sent to the publishers. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. 9 8 7 6 5 4 3 2 1 Springer Science+Business Media springer.com
Foreword to the First Edition
Before the mid-1990s, very few people were aware of the disease of osteoporosis, not only in the general population, but also in the medical profession. In the past 10 years there have been many advances and developments in the understanding of this crippling disease, to the point that this therapeutic field has lost its “fledgling” status and has grown up rapidly. This is well demonstrated by the number of effective therapies that are available, the new methodologies for the diagnosis and monitoring of the disease, and the fact that the importance of osteoporosis, as a disease, is now recognised and is taught as an integral part of the syllabus in most medical schools. With the maturation of this therapeutic area, it has now become a challenge for physicians, scientists, and technologists to gain an easy understanding of the intricacies of running studies or clinical trials in osteoporosis. This book provides an excellent introduction and handbook for those wishing to pursue research i
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