Clinical Use of Anti-infective Agents A Guide on How to Prescribe Dr
This book is an overview of the clinical approach to the use of anti-infective agents. A brief description of the drugs used to treat infections is followed by an analysis of approaches to diseases ca
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Robert W. Finberg
●
Roy Guharoy
Clinical Use of Anti-infective Agents A Guide on How to Prescribe Drugs Used to Treat Infections
Robert W. Finberg Richard Haidack Professor and Chair Department of Medicine University of Massachusetts Medical School Worcester, MA, USA [email protected]
Roy Guharoy Chief Pharmacy Officer UMass Memorial Health Care Clinical Professor of Medicine University of Massachusetts Medical School Worcester, MA, USA [email protected]
ISBN 978-1-4614-1067-6 e-ISBN 978-1-4614-1068-3 DOI 10.1007/978-1-4614-1068-3 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011942229 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Contents
Part I
Introduction to Anti-infective Therapy, Structures and Mechanisms of Action of Commonly Used Antibacterial Agents
1
Introduction and History .......................................................................
3
2
Basic Principles of Drug Delivery and Dosing...................................... Mechanism of Actions of Anti-bacterial Agents ...................................... Role of Pharmacokinetics and Pharmacodynamics in the Management of Bacterial Infectious Diseases ................................ PK/PD Profiles of Anti-microbial Agents................................................. Time-Dependent Agents (Duration of Exposure to a Specific MIC) ..................................................................................... Concentration-Dependent Killing ............................................................. Pharmacokinetic Variability ...................................................................... Renal Impairment...................................................................................... Hepatic Impairment .................................................................................. Critically Ill Patients ................................................................................. Tissue Concentrations ............................................................................... Bacteriostatic Versus Bactericidal Drugs .................................................. Conclusion ....................................................
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