Clinical Guide to Heart Transplantation
This handbook is an easy reference for those involved in the management of heart transplant. While this compilation of best practices cannot address the complexity of the individual patients we care for on a daily basis, it will serve to help us ask
- PDF / 7,099,474 Bytes
- 258 Pages / 504.63 x 737.01 pts Page_size
- 34 Downloads / 360 Views
Clinical Guide to Heart Transplantation
123
Clinical Guide to Heart Transplantation
Jon Kobashigawa Editor
Clinical Guide to Heart Transplantation
Editor Jon Kobashigawa Director Advanced Heart Disease Section Cedars-Sinai Heart Institute Los Angeles, CA USA Director Heart Transplant Program Cedars-Sinai Heart Institute Los Angeles, CA USA
ISBN 978-3-319-43771-2 ISBN 978-3-319-43773-6 (eBook) DOI 10.1007/978-3-319-43773-6 Library of Congress Control Number: 2017936196 © Springer International Publishing AG 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Introduction
Since the first successful human heart transplant surgery in 1967 by Christiaan Barnard, the field of heart transplantation has evolved from a novel investigational pursuit to an established therapy for the treatment of end-stage heart failure. With the advent of improved surgical techniques, the development of immunosuppressive drugs and the utilization of more sophisticated monitoring strategies and treatments for graft rejection, heart transplantation now offers patients an avenue to both improved survival and quality of life. In the early years of thoracic transplantation, allograft rejection had been the main challenge limiting survival. Acceptable survival rates only evolved with the introduction of effective immunosuppressive agents. Rejection rates sharply declined as did infection rates as host responses to bacterial and fungal infection were relatively preserved with the new immunosuppressive regimens. The improvements in morbidity and mortality led to a remarkable expansion in heart transplantation. Currently, around 4100 heart transplants per year are being performed globally with a half-life of 11 years, with 1-year survival approaching 90%. Equally important, gre
Data Loading...
