Clinico-Pathological Profile of Women with Gynaecological Malignancies at a Tertiary Care Institute in South India
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ORIGINAL ARTICLE
Clinico-Pathological Profile of Women with Gynaecological Malignancies at a Tertiary Care Institute in South India Sonal Garg1 • Paapa Dasari1 Received: 19 April 2020 / Revised: 10 June 2020 / Accepted: 4 July 2020 Ó Association of Gynecologic Oncologists of India 2020
Abstract Purpose Worldwide gynaecological cancers comprise the most common cancers among all cancers affecting women. Most of the women present to us at an advanced stage in the developing countries. The aim of this study was to analyse the clinico-pathological profile of women with gynaecological malignancies presenting to a tertiary care institute in South India. The objective was to know the spectrum of malignancies with respect to age and stage of the disease at presentation. Methods Retrospective analysis of 558 women with gynaecological tumours who were managed in the Department of Obstetrics and Gynaecology, JIPMER, Puducherry, over a period of 2 years (January 2016–December 2017). Results Out of 558 women, 329 (58.9%) were found to be histologically proven malignancies. The most common cancer was found to be carcinoma cervix (40.1%) followed by ovarian carcinoma (28.8%). Carcinoma endometrium constituted 28.57%, and 2.43% were other malignancies. The most common age group at presentation was 60–69 years for carcinoma cervix; for carcinoma ovary and endometrium, it was \ 60 years. Only 7.5% of carcinoma cervix were in stage I, compared to 74% of endometrial and 46% of ovarian cancers who were in stage I. Conclusion The most common gynaecological malignancy was carcinoma cervix and majority were in advanced stage. Only 7.5% were in stage I even though screening strategies are available for carcinoma cervix when compared to endometrial and ovarian cancers where there are no definite cost-effective screening strategies. This calls for adopting preventive strategies for carcinoma cervix like primary vaccination and implementing mandatory effective screening especially after 35 years. Keywords Gynaecological malignancies Stage of disease Age group Carcinoma cervix
Introduction Worldwide, the dreaded cancers in women are carcinoma breast, cervix, endometrium, ovary, colorectal, lung and liver. Cancer is the most common cause of death both in high-income and in middle-income countries. The burden of genital tract cancers as reported in 2012 was 5,27,600 cases of cervical cancer with 2,65,700 deaths, 3,19,600 cases of endometrial cancer and 2,38,700 cases of ovarian carcinoma [1]. In less developed nations, carcinoma cervix is the most common cause of death in women with gynaecological cancers. It was proven that prevention and & Paapa Dasari [email protected] 1
early detection interventions reduce the burden of cancer and morbidity in both high- and low-resource settings. The incidence and mortality rates are different in different regions of the world, within the country, and depend on the resources available and preventive and screening strategies adopted. Hence, it is important to know the common gynaecological cancer
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