Clopidogrel/recombinant factor VIIa
- PDF / 141,445 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 26 Downloads / 154 Views
1
S
Disseminated intravascular coagulation-like phenomenon and aortic valve thrombosis: case report A 60-year-old man developed a disseminated intravascular coagulation (DIC)-like phenomenon following administration of clopidogrel, and acute aortic valve thrombosis following administration of recombinant factor VIIa [NovoSeven RT]. The man was hospitalised for coronary artery bypass grafting, and underwent extracorporeal membrane oxygenation (ECMO). He was successfully treated for circumflex artery stenosis with a loading dose of clopidogrel [dosage and route not stated] and placement of a drug-eluting stent. He was transferred to an ICU, where massive bleeding from the chest tube was observed, attributed to a DIC-like phenomenon secondary to ECMO and clopidogrel [time to reaction onset not stated]. Recombinant factor VIIa 90 µg/kg was infused. About 2 hours later, the chest tube drainage had decreased. Eighteen hours after the procedure, the man received heparin. On postoperative day 1, echocardiography revealed severely depressed left ventricular function and a newly formed aortic thrombus, which progressed to complete thrombosis of the aortic valve on postoperative day 3. Subsequently, he died from multiorgan failure. Hajj-Chahine J, et al. Acute aortic valve thrombosis secondary to recombinant factor VIIa. Annals of Thoracic Surgery 93: 999, No. 3, Mar 2012. Available from: 803070534 URL: http://dx.doi.org/10.1016/j.athoracsur.2011.08.050 - France
0114-9954/10/1402-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 19 May 2012 No. 1402
Data Loading...
