CMR assessment of epicardial fat volume in human morbid obesity at 3 T: relationship to cardiac function and morphology
- PDF / 230,816 Bytes
- 2 Pages / 610 x 792 pts Page_size
- 37 Downloads / 160 Views
BioMed Central
Open Access
Poster presentation
CMR assessment of epicardial fat volume in human morbid obesity at 3 T: relationship to cardiac function and morphology Bénédicte Gaborit*1, Frank Kober2, Pierre-Julien Moro2, Alexis Jacquier2, Alexandre Vignaud2, Frédéric Dadoun2, Patrick J Cozzone2, Monique Bernard2 and Anne Dutour3 Address: 1Unité de recherche du syndrome métabolique, tissu adipeux et risque vasculaire, UMR U626, Centre de Résonance Magnétique Biologique et Médicale, CNRS UMR N°6612, Université de la Méditerranée, Marseille, France, 2Centre de Résonance Magnétique Biologique et Médicale, CNRS UMR N°6612, Université de la Méditerranée, Marseille, France and 3Unité de recherche du syndrome métabolique, tissu adipeux et risque vasculaire, UMR U626, Université de la Méditerranée, Marseille, France * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P268
doi:10.1186/1532-429X-12-S1-P268
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/P268 © 2010 Gaborit et al; licensee BioMed Central Ltd.
Introduction Ectopic fat accumulation within and around the myocardium is involved in the pathogenesis of obesity-related cardiomyopathy and cardiovascular disease. Earlier MR studies have been restricted to a mildly obese population due to magnet bore size limitations. For this study, a 70 cm bore 3 tesla MR system offered the possibility to assess left-ventricular (LV) morphology and function along with EFV in patients with severe obesity.
Purpose To assess epicardial fat volume (EFV) in severely obese patients with CMR at 3 T, and to determine its potential correlations with left-ventricular function and morphology.
Methods CMR was performed with a Siemens Verio 3 T system in 24 obese patients (15 with morbid obesity and 9 with diabetes, mean BMI = 42.3 ± 5.7 kg/m2) and in 14 healthy controls (mean BMI = 22.4 ± 2.1 kg/m2). The scanner was equipped with a 32-channel phased-array coil. Sixteen short-axis slices covering the heart and its surrounding adipose tissue were obtained within four breathholds using a balanced SSFP cine sequence with 4-fold GRAPPA k-space reduction (FOV = 340 × 340 mm2, TE = 1.2 ms, TR
= 61 ms, matrix = 134 × 192, slice thickness 6 mm). The absolute volume of epicardial fat was assessed by manual delineation on every slice from base to apex. Parameters of LV function and morphology were obtained using the same short-axis dataset. All patients underwent an intraabdominal CT scan for visceral adipose tissue (VAT) assessment and biological evaluation.
Results EFV was increased twofold between lean (64 ± 29 mL) and obese non-diabetic (123 ± 44 mL) subjects. Another twofold increase in EFV was obser
Data Loading...
