Use of Infrared Thermography to Estimate Brown Fat Activation After a Cooling Protocol in Patients with Severe Obesity T
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ORIGINAL CONTRIBUTIONS
Use of Infrared Thermography to Estimate Brown Fat Activation After a Cooling Protocol in Patients with Severe Obesity That Underwent Bariatric Surgery Irene Piquer-Garcia 1 & Rubén Cereijo 2,3 & Juan Corral-Pérez 4,5 & Silvia Pellitero 1,6 & Eva Martínez 1 & Siri D. Taxerås 1 & Jordi Tarascó 1 & Pau Moreno 1 & José Balibrea 7 & Manel Puig-Domingo 1,6 & Dolors Serra 3,8 & Laura Herrero 3,8 & David Jiménez-Pavón 4,5 & Carles Lerin 9 & Francesc Villarroya 2,3 & David Sánchez-Infantes 1,3,10
# Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background In contrast to the energy-storing role of white adipose tissue (WAT), brown adipose tissue (BAT) acts as the main site of non-shivering thermogenesis in mammals and has been reported to play a role in protection against obesity and associated metabolic alterations in rodents. Infrared thermography (IRT) has been proposed as a novel non-invasive, safe, and quick method to estimate BAT thermogenic activation in humans. The aim of this study is to determine whether the IRT could be a potential new tool to estimate BAT thermogenic activation in patients with severe obesity in response to bariatric surgery. Methods Supraclavicular BAT thermogenic activation was evaluated using IRT in a cohort of 31 patients (50 ± 10 years old, BMI = 44.5 ± 7.8; 15 undergoing laparoscopy sleeve gastrectomy and 16 Roux-en-Y gastric bypass) at baseline and 6 months after a bariatric surgery. Clinical parameters were determined at these same time points. Results Supraclavicular BAT-related activity was detected in our patients by IRT after a cooling stimulus. The BAT thermogenic activation was higher at 6 months after laparoscopy sleeve gastrectomy (0.06 ± 0.1 vs 0.32 ± 0.1), while patients undergoing to a roux-en-Y gastric bypass did not change their thermogenic response using the same cooling stimulus (0.09 ± 0.1 vs 0.08 ± 0.1). Conclusions Our study postulates the IRT as a potential tool to evaluate BAT thermogenic activation in patients with obesity before and after a bariatric surgery. Further studies are needed to evaluate differences between LSG technique and RYGB on BAT activation. Keywords Infrared thermography . Brown adipose tissue . Obesity . Metabolic surgery
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11695-020-04502-7) contains supplementary material, which is available to authorized users. * David Sánchez-Infantes [email protected]
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Centro de Investigación Biomédica en Fisiopatología de la Diabetes y enfermedades metabólicas (CIBERDEM), ISCIII, Madrid, Spain
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Metabolic and Bariatric Surgery Unit, EAC-BS Center of Excellence, Vall d’Hebron University Hospital, Barcelona, Spain
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Centro de Investigación Biomédica de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain
Department of Biochemistry and Physiology, School of Pharmacy, Institut de Biomedicina de la Universitat de Barcelona (IBUB),, Universitat de Barcelon
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