Co-expression of intermediate filaments glial fibrillary acidic protein and cytokeratin in pituitary adenoma
- PDF / 1,108,283 Bytes
- 6 Pages / 595.276 x 790.866 pts Page_size
- 68 Downloads / 179 Views
Co‑expression of intermediate filaments glial fibrillary acidic protein and cytokeratin in pituitary adenoma Nina Wiesnagrotzki1 · Christian Bernreuther2 · Wolfgang Saeger1,2 · Jörg Flitsch3 · Markus Glatzel1 · Christian Hagel1 Accepted: 22 September 2020 © The Author(s) 2020
Abstract Purpose To analyze the co-expression of the intermediate filaments GFAP and cytokeratin in 326 pituitary adenomas with regard to the distribution pattern, the subtype of the adenoma and clinical prognostic data. Methods Tissue from 326 pituitary adenomas and 13 normal anterior pituitaries collected in the Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, between 2006 and 2009 was investigated by immunohistochemistry, immunofluorescence and electron microscopy. Results Co-expression of intermediate filaments GFAP and cytokeratin was associated with hormone expression in 62/278 cases (22%), but only found in 2/48 (4%) of null cell adenomas (p
Data Loading...
