Co-signal Molecules in T Cell Activation Immune Regulation in Health
This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted
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Miyuki Azuma Hideo Yagita Editors
Co-signal Molecules in T Cell Activation Immune Regulation in Health and Disease
Advances in Experimental Medicine and Biology Volume 1189
Series Editors Wim E. Crusio, CNRS and University of Bordeaux UMR 5287, Institut de Neurosciences Cognitives et Intégratives d’Aquitaine, Pessac Cedex, France John D. Lambris, University of Pennsylvania, Philadelphia, PA, USA Nima Rezaei, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran
More information about this series at http://www.springer.com/series/5584
Miyuki Azuma • Hideo Yagita Editors
Co-signal Molecules in T Cell Activation Immune Regulation in Health and Disease
Editors Miyuki Azuma Department of Molecular Immunology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo, Japan
Hideo Yagita Department of Immunology Juntendo University School of Medicine Tokyo, Japan
ISSN 0065-2598 ISSN 2214-8019 (electronic) Advances in Experimental Medicine and Biology ISBN 978-981-32-9716-6 ISBN 978-981-32-9717-3 (eBook) https://doi.org/10.1007/978-981-32-9717-3 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Contents
Part I Basic Understanding of Co-signal Molecules in T Cell Activation 1 Co-signal Molecules in T-Cell Activation ���������������������������������������������� 3 Miyuki Azuma 2 The CD28–B7 Family of Co-signaling Molecules��������������������������������� 25 Shigenori Nagai and Miyuki Azuma 3 The TNF–TNFR Family of Co-signal Molecules���������������������������������� 53 Takanori So and Naoto Ishii 4 Signal Transduction Via Co-stim
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