Cell Communication in Nervous and Immune System
At first glance, the nervous and immune systems appear very different. However, both systems have developed mechanisms for memory formation – though of quite different quality and significance for the organism. One striking example is that both systems fo
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Series Editors D. Richter, H. Tiedge
Eckart D. Gundelfinger, Constanze I. Seidenbecher, Burkhart Schraven (Eds.)
Cell Communication in Nervous and Immune System With 28 Figures, 8 in Color, and 3 Tables
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Professor Dr. Eckart D. Gundelfinger Dr. Constanze I. Seidenbecher Leibniz Institut für Neurobiologie Abteilung Neurochemie und Molekularbiologie Brenneckestr. 6 39118 Magdeburg Germany gundelfi[email protected]
Professor Dr. Burkhart Schraven Institut für Immunologie Otto-von-Guericke-Universität Magdeburg Leipzigerstrasse 44 3120 Magdeburg [email protected]
ISSN 0080-1844 ISBN-10 3-540-36828-0 Springer Berlin Heidelberg New York ISBN-13 978-3-540-36828-1 Springer Berlin Heidelberg New York Library of Congress Control Number: 2006932575
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Preface
Signal exchange between cells is a key feature of life from humble monads to human beings. Appropriate communication is of particular importance between cells of multi-cellular organisms. Various basic mechanisms of cell– cell communication have evolved during phylogenesis, which were subject to organ, tissue and cell type-specific adaptation. These mechanisms range from long-distance communication via hormones to more and more local processes, e.g. via cytokines, chemokines or neuromodulators/neurotransmitters, and eventually direct physical interactions of molecules anchored at cell surfaces. Accordingly, highly specialized transient or stable cell–cell contact sites have evolved that mediate signaling between cells. With few exceptions (e.g. lipophilic hormones, gases) intercellular communication depends on specific signal detection devices at the cell surface coupled to a signal transduction apparatus that mediates the signal transfer across the cell membrane and activates intracellular effector systems, which generate intracellularly decipherable signals. Prime examples for tissues of intensely communicating cells are
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