Cohort profile: Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO)
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COHORT PROFILE
Cohort profile: Singapore Preconception Study of Long‑Term Maternal and Child Outcomes (S‑PRESTO) Evelyn Xiu Ling Loo1,2 · Shu‑E Soh2 · See Ling Loy1,3,4 · Sharon Ng5 · Mya Thway Tint5 · Shiao‑Yng Chan1,5 · Jonathan Yinhao Huang1 · Fabian Yap4,6,7 · Kok Hian Tan4,8 · Bernard S. M. Chern9 · Heng Hao Tan3 · Michael J. Meaney1,10 · Neerja Karnani1,11 · Keith M. Godfrey12,13 · Yung Seng Lee1,2,14 · Jerry Kok Yen Chan3,4 · Peter D. Gluckman1,15 · Yap‑Seng Chong1,5 · Lynette Pei‑Chi Shek1,2,14 · Johan G. Eriksson1,5,16,17 · the S-PRESTO Study Group · Airu Chia · Anna Magdalena Fogel · Anne Eng Neo Goh · Anne Hin Yee Chu · Anne Rifkin‑Graboi · Anqi Qiu · Bee Wah Lee · Bobby Kyungbeom Cheon · Candida Vaz · Christiani Jeyakumar Henry · Ciaran Gerard Forde · Claudia Chi · Dawn Xin Ping Koh · Desiree Y. Phua · Doris Ngiuk Lan Loh · Elaine Phaik Ling Quah · Elizabeth Huiwen Tham · Evelyn Chung Ning Law · Faidon Magkos · Falk Mueller‑Riemenschneider · George Seow Heong Yeo · Hannah Ee Juen Yong · Helen Yu Chen · Heng Hao Tan · Hong Pan · Hugo P S van Bever · Hui Min Tan · Izzuddin Bin Mohd Aris · Jeannie Tay · Jerry Kok Yen Chan · Jia Xu · Joanne Su‑Yin Yoong · Johan Gunnar Eriksson · Jonathan Tze Liang Choo · Jonathan Y. Bernard · Jonathan Yinhao Huang · Jun Shi Lai · Karen Mei Ling Tan · Keith M. Godfrey · Kenneth Yung Chiang Kwek · Keri McCrickerd · Kothandaraman Narasimhan · Kok Wee Chong · Kuan Jin Lee · Li Chen · Lieng Hsi Ling · Ling‑Wei Chen · Lourdes Mary Daniel · Lynette Pei‑Chi Shek · Marielle V. Fortier · Mary Foong‑Fong Chong · Mei Chien Chua · Melvin Khee‑Shing Leow · Michelle Zhi Ling Kee · Min Gong · Mya Thway Tint · Navin Michael · Ngee Lek · Oon Hoe Teoh · Priti Mishra · Queenie Ling Jun Li · Sambasivam Sendhil Velan · Seng Bin Ang · Shirong Cai · Si Hui Goh · Sok Bee Lim · Stella Tsotsi · Stephen Chin‑Ying Hsu · Sue‑Anne Ee Shiow Toh · Suresh Anand Sadananthan · Teng Hong Tan · Tong Wei Yew · Varsha Gupta · Victor Samuel Rajadurai · Wee Meng Han · Wei Wei Pang · Wen Lun Yuan · Yanan Zhu · Yin Bun Cheung · Yiong Huak Chan · Zai Ru Cheng Received: 10 September 2019 / Accepted: 7 November 2020 © Springer Nature B.V. 2020
Abstract The Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) is a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outcomes including duration of gestation, fetal growth, metabolic and neural phenotypes in the offspring. Between February 2015 and October 2017, the S-PRESTO study recruited 1039 Chinese, Malay or Indian (or any combinations thereof) women aged 18–45 years and who intended to get pregnant and deliver in Singapore, resulting in 1032 unique participants and 373 children born in the cohort. The participants were followed up for 3 visits during the preconception phase and censored at 12 months of follow up if pregnancy was not achieved (N = 557 censored). Women who successfully con
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