Color-Coded Method Visualizes Drug Release in Cancer Cells
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10/31/2006
12:09 PM
Page 846
Letter from the President
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RESEARCH/RESEARCHERS
Color-Coded Method Visualizes Drug Release in Cancer Cells Philip Low, the Ralph C. Corley Distinguished Professor of Chemistry at Purdue University, and his colleagues at Purdue and Endocyte Inc., have discovered details of how drugs are released within a cancer cell, improving the ability to deliver drugs to a specific target without affecting surrounding cells. “Most new drugs under development will be targeted directly to the pathologic, diseasecausing cells, and we have shed light on the details of one mechanism by which this is achieved,” Low said. As reported in the September 12 issue of the Proceedings of the National Academy of Sciences (p. 13872; 10.1073/pnas. 0601455103), Low and his team developed a color-coded method to visualize the cellular mechanisms by using a technique called fluorescence resonance energy transfer imaging (see Figure 1). “The drug turns from red to green when it is released inside the cell, clearly illuminating the process,” said Jun Yang, a postdoctoral research associate in Low
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