Electrospun Fibre Composite for Controlled Drug Release
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MRS Advances © 2020 Materials Research Society DOI: 10.1557/adv.2020.268
Electrospun Fibre Composite for Controlled Drug Release Ryan Go1^, Shadi Houshyar1^*, Kate Fox1,2, Yen Bach Truong3* 1
School of Engineering, RMIT University, Melbourne, Vic 3000, Australia
2
Center for Additive Manufacturing, RMIT University, Melbourne, Vic 3000, Australia
3
CSIRO Manufacturing, Private Bag 10, Clayton South, VIC, 3169, Australia.
E-mail: [email protected] and [email protected]
Abstract:
A drug delivery system with sustainable controlled drug release can improve the quality of life of a patient by reducing the side-effects and better absorption of the drug locally. However, the main disadvantageous of this delivery model is the burst release of the drug, which can result in severe health problem, such as toxicity. Here in this study, a new coaxial microfiber has been developed with encapsulated anti-inflammatory drug, ibuprofen, inside the core structure of the coaxial fibre. The core consisting of polyethylene oxide (PEO) carrying the drug was covered with the polylactic acid (PLA)/PEO and shell to prevent the burst release of the drug and provide sustainable release over a prolonged time. The release profiles showed that the burst release was reduced from 20% in control scaffold, core only, to 5% in core-shell structure after 6 hrs. The higher percentage of PLA in the shell composition provides a slower release of ibuprofen, due to the slower degradation of PLA in comparison with PEO. The result indicates the developed structure can be a potential system for the localized release of the various drug system, which leads to a more sustainable and controlled release of the drug over the more extended period and deliver a better outcome along with side-effect prevention. 1
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INTRODUCTION: A controlled release drug delivery system has many advantages over conventional dosage forms, such as improving therapeutic efficiency, reducing toxicity and side effects.[1, 2] In general, controlled release dosage forms are designed with the purpose of maintaining relatively steady concentrations of the drug in the tissue, blood or targeted organs for prolong period. Research on the improvement of drug release mainly surrounds the issue of successfully combining a hydrophilic drug with a hydrophobic capsule or scaffold. The hydrophilic character of the drug causes the high rate of release, while the hydrophobic nature of scaffold controls the release by slowing down the degradation and solubility in the media. [3-6] Recently, many drug delivery systems have been investigated including various structure such as film [7, 8], wafer [9, 10], micro/nanofibers [2, 11, 12] and micro/nanoparticles [11, 13, 14] and various polymers such as PLA, PCL, PVA and chitosan.[12, 15-19] Among all of them, m
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