Combined application of DTI and BOLD-MRI in the assessment of renal injury with hyperuricemia
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Combined application of DTI and BOLD‑MRI in the assessment of renal injury with hyperuricemia Zhong‑Yuan Cheng1 · Qi‑Ting Lin1 · Ping‑Kang Chen1 · Ding‑Kun Si‑Tu1 · Long Qian2 · You‑Zhen Feng1 · Xiang‑Ran Cai1 Received: 30 June 2020 / Revised: 20 September 2020 / Accepted: 30 September 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Objective To explore the value of combined diffusion tensor imaging (DTI) and blood oxygenation level-dependent magnetic resonance imaging (BOLD-MRI) in detecting early renal alterations in patients with hyperuricemia. Materials and methods Seventy-one individuals were enrolled in this study and divided into three groups according to their serum uric acid (SUA) level and clinical symptoms: healthy controls (HC, n = 23), asymptomatic hyperuricemia (AH, n = 22) and gouty arthritis (GA, n = 26). All patients underwent both DTI and BOLD-MRI examination. Renal cortical and medullary ADC, FA and R2* values were calculated, respectively, and compared among the three groups. Correlations between ADC, FA and R2* with estimated glomerular filtration rate (eGFR) and SUA in hyperuricemia were evaluated, respectively. Result In the renal cortex, the ADC, FA and R2* values of the AH and GA groups were significantly lower than those of the HC groups (p
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