Combined large cell neuroendocrine carcinoma with giant cell carcinoma of the lungs: a case report
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Combined large cell neuroendocrine carcinoma with giant cell carcinoma of the lungs: a case report Hayashi et al. Hayashi et al. World Journal of Surgical Oncology 2013, 11:205 http://www.wjso.com/content/11/1/205 (19 August 2013)
Hayashi et al. World Journal of Surgical Oncology 2013, 11:205 http://www.wjso.com/content/11/1/205
WORLD JOURNAL OF SURGICAL ONCOLOGY
CASE REPORT
Open Access
Combined large cell neuroendocrine carcinoma with giant cell carcinoma of the lungs: a case report Satoshi Hayashi1*, Masahiro Kitada1, Kei Ishibashi1, Yoshinari Matsuda1 and Naoyuki Miyokawa2
Abstract Combined large cell neuroendocrine carcinoma of the lungs (combined LCNEC) with giant cell carcinoma is extremely rare. A 65-year-old man was found to have an abnormal shadow in his left lung field. Computed tomography revealed a solid, round mass measuring 2.8 × 2.2 cm that was located in the left S9. The patient underwent left lower lobectomy and mediastinal lymph node dissection. Histopathological examination revealed an LCNEC, combined with giant cell carcinoma. The patient received by S-1 (TS-1, an oral fluoropyrimidine) chemotherapy, and he has been disease-free for over 8 months. Combined LCNEC with giant cell carcinoma is an extremely rare tumor with high malignant potential, and thus, multidisciplinary therapy and close follow-up are advised. Keywords: Combined large cell neuroendocrine carcinoma, Lung, Giant cell carcinoma
Background Combined large cell neuroendocrine carcinoma (combined LCNEC) is a rare histological type of primary lung carcinoma that has components of adenocarcinoma, squamous cell carcinoma, giant cell carcinoma, and/or spindle cell carcinoma. In 1999, the World Health Organization (WHO) categorized combined LCNEC as a variant of large cell carcinoma (LCC). Combined LCNEC accounts for only 10.6% of all LCNECs. In this context, we report a case of combined LCNEC with giant cell carcinoma that we encountered recently. Case presentation A 65-year-old man was found to have an abnormal shadow in his left lung field. A mass was detected in the left middle lung field on a chest radiograph (Figure 1A). Computed tomography (CT) revealed a solid, round mass measuring 2.8 × 2.2 cm located in the left S9 (Figure 1B). No mediastinal lymph node swelling or other organ metastases were observed. On positron emission tomography with 18F-fluorodeoxyglucose examination, the maximum * Correspondence: [email protected] 1 Respiratory Center, Asahikawa Medical University Hospital, Midorigaoka-Higashi 2-1-1-1, Asahikawa, Hokkaido, Japan Full list of author information is available at the end of the article
standardized uptake value was 12.1, which corresponded to the tumor findings on CT (Figure 1C). Biochemical blood examinations did not reveal abnormalities, and the levels of the tumor markers carcinoembryonic antigen (CEA), squamous cell carcinoma antigen, Cyfra21-1/cytokeratin 19 fragment, and pro-gastrin-releasing peptide were 3.0 ng/ml, 1.9 ng/ml, 2.1 ng/ml, and 30.9 pg/ml, respectively. The patient had
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