A case of esophageal squamous cell carcinoma with neuroendocrine, basaloid, and ciliated glandular differentiation
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CASE REPORT
A case of esophageal squamous cell carcinoma with neuroendocrine, basaloid, and ciliated glandular differentiation Tomoaki Yamasaki1 · Naomi Ishii2 · Takahiro Okuno2 · Takehisa Suekane1 · Takeshi Inoue2 · Hiroko Nebiki1 Received: 7 August 2020 / Accepted: 7 October 2020 © Japanese Society of Gastroenterology 2020
Abstract Esophageal carcinomas have multidirectional differentiation abilities and different histological components have been reported. Herein, we report a case of esophageal carcinoma with four different differentiations. A 64-year-old man was referred to our hospital for treatment of an esophageal tumor detected during an esophagogastroduodenoscopy, which revealed an elevated lesion accompanied by a slightly depressed lesion in the middle of the esophagus. Examination of the biopsy specimen obtained from the elevated lesion revealed an adenocarcinoma, while that from the depressed lesion revealed a squamous cell carcinoma. Fluorodeoxyglucose-position emission tomography and enhanced computed tomography showed an esophageal carcinoma in the middle of the esophagus with no signs of metastasis. The preoperative diagnosis was adenosquamous cell carcinoma classified as T2N0M0 according to the TNM classification (seventh edition). Thoracoscopic esophagectomy was performed. Examination of the resected specimen revealed esophageal squamous cell carcinoma with neuroendocrine, basaloid, and ciliated glandular differentiation. Although they may be totipotent, an esophageal carcinoma consisting of four components is extremely rare. Moreover, ciliated glandular differentiation is rarely observed in the esophagus, except in individuals with bronchial esophageal duplication cysts and adenocarcinoma arises from a Barrett’s esophagus. Keywords Esophageal squamous cell carcinoma · Ciliated glandular differentiation · Basaloid · Neuroendocrine
Introduction Squamous cell carcinoma is a histological type of esophageal carcinoma that commonly occurs among people in the Asian and African countries; however, the incidence of esophageal adenocarcinoma has recently been increasing in Western countries [1]. Basaloid cell carcinoma, carcinosarcoma, and neuroendocrine cell carcinoma are rare histological types. The histological components of esophageal carcinoma are not always pure because this form of cancer has multidirectional differentiation abilities [2, 3]. Thus, esophageal carcinomas with two or more different
* Tomoaki Yamasaki [email protected] 1
Department of Gastroenterology, Osaka City General Hospital, 2‑13‑22, Miyakojima‑hondori, Miyakojima‑ku, Osaka 534‑0021, Japan
Department of Pathology, Osaka City General Hospital, 2‑13‑22, Miyakojima‑hondori, Miyakojima‑ku, Osaka 534‑0021, Japan
2
histological types have been reported. However, esophageal carcinomas with four components are extremely rare. We herein describe the clinicopathological features of esophageal squamous cell carcinoma with neuroendocrine, basaloid, and ciliated glandular differentiation.
Case report A 64-year-old man
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