Combined use of preoperative 18 F FDG-PET imaging and intraoperative gamma probe detection for accurate assessment of tu
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Combined use of preoperative 18F FDG-PET imaging and intraoperative gamma probe detection for accurate assessment of tumor recurrence in patients with colorectal cancer Ismet Sarikaya*1, Stephen P Povoski2, Osama H Al-Saif2, Ergun Kocak2, Mark Bloomston2, Steven Marsh1, Zongjian Cao3, Douglas A Murrey2, Jun Zhang1, Nathan C Hall1, Michael V Knopp1 and Edward W Martin Jr2 Address: 1Division of Nuclear Medicine, Section of PET, Department of Radiology, The Ohio State University, Columbus, OH 43210, USA, 2Division of Surgical Oncology, Department of Surgery, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA and 3Department of Radiology, Medical College of Georgia, Augusta, GA 30912, USA Email: Ismet Sarikaya* - [email protected]; Stephen P Povoski - [email protected]; Osama H AlSaif - [email protected]; Ergun Kocak - [email protected]; Mark Bloomston - [email protected]; Steven Marsh - [email protected]; Zongjian Cao - [email protected]; Douglas A Murrey - [email protected]; Jun Zhang - [email protected]; Nathan C Hall - [email protected]; Michael V Knopp - [email protected]; Edward W Martin - [email protected] * Corresponding author
Published: 16 July 2007 World Journal of Surgical Oncology 2007, 5:80
doi:10.1186/1477-7819-5-80
Received: 15 May 2007 Accepted: 16 July 2007
This article is available from: http://www.wjso.com/content/5/1/80 © 2007 Sarikaya et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: The purpose of this study was to combine intraoperative gamma probe (GP) detection with preoperative fluorine 18-fluoro-2-deoxy-glucose positron emission tomography (18F FDG-PET) imaging in order to improve detection of tumor recurrence in colorectal cancer (CRC) patients. Methods: Twenty-one patients (12 females, 9 males) with a mean age of 54 years (range 31–78) were enrolled. Patients were suspected to have recurrent CRC by elevated CEA (n = 11), suspicious CT findings (n = 1), and clinically suspicious findings (n = 9). Preoperative FDG-PET scan and intraoperative GP study were performed in all patients. Mean time interval between preoperative FDG-PET scan and surgery was 16 days (range 1–41 days) in 19 patients. For intraoperative GP studies, 19 patients were injected with a dose of 10–15 mCi 18F FDG at approximately 30 minutes before the planned surgery time. In two patients, the intraoperative GP study was performed immediately after preoperative FDG-PET scan. Results: Preoperative FDG-PET and intraoperative GP detected 48 and 45 lesions, respectively. A total of 50 presumed site of recurrent disease from 20 patients were resected. Thirty-seven of
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