Combined approach of perioperative 18 F-FDG PET/CT imaging and intraoperative 18 F-FDG handheld gamma probe detection fo
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Combined approach of perioperative 18F-FDG PET/CT imaging and intraoperative 18F-FDG handheld gamma probe detection for tumor localization and verification of complete tumor resection in breast cancer Nathan C Hall*1, Stephen P Povoski2, Douglas A Murrey2, Michael V Knopp1 and Edward W Martin Jr2 Address: 1Section of PET, Division of Nuclear Medicine, Department of Radiology, The Ohio State University, Columbus, OH, 43210, USA and 2Division of Surgical Oncology, Department of Surgery, Arthur G. James Cancer Hospital and Richard J. Solove Research Institute and Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA Email: Nathan C Hall* - [email protected]; Stephen P Povoski - [email protected]; Douglas A Murrey - [email protected]; Michael V Knopp - [email protected]; Edward W Martin - [email protected] * Corresponding author
Published: 21 December 2007 World Journal of Surgical Oncology 2007, 5:143
doi:10.1186/1477-7819-5-143
Received: 30 August 2007 Accepted: 21 December 2007
This article is available from: http://www.wjso.com/content/5/1/143 © 2007 Hall et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/ CT) has become an established method for detecting hypermetabolic sites of known and occult disease and is widely used in oncology surgical planning. Intraoperatively, it is often difficult to localize tumors and verify complete resection of tumors that have been previously detected on diagnostic PET/CT at the time of the original evaluation of the cancer patient. Therefore, we propose an innovative approach for intraoperative tumor localization and verification of complete tumor resection utilizing 18F-FDG for perioperative PET/CT imaging and intraoperative gamma probe detection. Methods: Two breast cancer patients were evaluated. 18F-FDG was administered and PET/CT was acquired immediately prior to surgery. Intraoperatively, tumors were localized and resected with the assistance of a handheld gamma probe. Resected tumors were scanned with specimen PET/CT prior to pathologic processing. Shortly after the surgical procedure, patients were re-imaged with PET/CT utilizing the same preoperatively administered 18F-FDG dose. Results: One patient had primary carcinoma of breast and a metastatic axillary lymph node. The second patient had a solitary metastatic liver lesion. In both cases, preoperative PET/CT verified these findings and demonstrated no additional suspicious hypermetabolic lesions. Furthermore, intraoperative gamma probe detection, specimen PET/CT, and postoperative PET/CT verified complete resection of the hypermetabolic lesions. Conclusion: Immedia
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