Comparing EQ-5D-3L and EQ-5D-5L performance in common cancers: suggestions for instrument choosing
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Comparing EQ‑5D‑3L and EQ‑5D‑5L performance in common cancers: suggestions for instrument choosing Juan Zhu1,8 · Xin‑Xin Yan1 · Cheng‑Cheng Liu1 · Hong Wang1 · Le Wang1 · Su‑Mei Cao2 · Xian‑Zhen Liao3 · Yun‑Feng Xi4 · Yong Ji5 · Lin Lei6 · Hai‑Fan Xiao3 · Hai‑Jing Guan7 · Wen‑Qiang Wei8 · Min Dai1 · Wanqing Chen1 · Ju‑Fang Shi1 Accepted: 7 September 2020 © Springer Nature Switzerland AG 2020
Abstract Purpose To compare the performance of three-level EuroQol five-dimensions (EQ-5D-3L) and five-level EuroQol fivedimensions (EQ-5D-5L) among common cancer patients in urban China. Methods A hospital-based cross-sectional survey was conducted in three provinces from 2016 to 2018 in urban China. Patients with breast cancer, colorectal cancer, or lung cancer were recruited to complete the EQ-5D-3L and EQ-5D-5L questionnaires. Response distribution, discriminatory power (indicator: Shannon index [H′] and Shannon evenness index [J′]), ceiling effect (the proportion of full health state), convergent validity, and health-related quality of life (HRQoL) were compared between the two instruments. Results A total of 1802 cancer patients (breast cancer: 601, colorectal cancer: 601, lung cancer: 600) were included, with the mean age of 55.6 years. The average inconsistency rate was 4.4%. Compared with EQ-5D-3L (average: H′ = 1.100, J′ = 0.696), an improved discriminatory power was observed in EQ-5D-5L (H′ = 1.473, J′ = 0.932), especially contributing to anxiety/depression dimensions. The ceiling effect was diminished in EQ-5D-5L (26.5%) in comparison with EQ-5D-3L (34.5%) (p
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