Comparing the efficacy and safety of Q-switched and picosecond lasers in the treatment of nevus of Ota: a systematic rev
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ORIGINAL ARTICLE
Comparing the efficacy and safety of Q-switched and picosecond lasers in the treatment of nevus of Ota: a systematic review and meta-analysis Natalie M. Williams 1 & Pooja Gurnani 1 & Jun Long 1 & John Reynolds 2 & Yue Pan 3 & Takahiro Suzuki 1 & Ghadah I. Alhetheli 1,4 & Keyvan Nouri 1 Received: 15 July 2020 / Accepted: 10 August 2020 # Springer-Verlag London Ltd., part of Springer Nature 2020
Abstract Nevus of Ota is cosmetically burdensome and often prompts patients to seek treatment. Lasers are commonly used in removing these lesions; however, no systemic analysis has been conducted to support a gold standard laser. To conduct a meta-analysis of the efficacy and safety of Q-switched Nd:YAG lasers (QSNL), Q-switched ruby lasers (QSRL), Q-switched alexandrite lasers (QSAL), and picosecond alexandrite lasers (PSAL) in removing nevus of Ota. Inclusion criteria were nevus of Ota patients treated with QSNL, QSRL, QSAL, or PSAL and documentation of percent clearance and the rate of at least one adverse event. Articles in English, Chinese, or Japanese were included. The prespecified outcome measures were efficacy (percent clearance) and safety (rates of hyperpigmentation, hypopigmentation, scarring, and recurrence). The review included 57 studies and 13,417 patients. The pooled success rate was 64% for QSNL (95% CI 52–76%), 54% for QSRL (95% CI 39–69%), 58% for QSAL (95% CI 44–72%), and 100% for PSAL (95% CI 98–102%). The pooled adverse event rate was 5% for QSNL (95% CI 4–6%), 14% for QSRL (95% CI 9–19%), 9% for QSAL (95% CI 6–12%), and 44% (95% CI 31–57%) for PSAL. QSNL has the most evidence for effectively and safely treating nevus of Ota. PSAL potentially has a superior efficacy; however, further studies are needed to elucidate its side effect profile when treating nevus of Ota. Keywords Dermatology . Pigmented lesions . Nevus of Ota . Q-switched lasers . Picosecond lasers
Introduction Nevus of Ota, or oculodermal melanocytosis, is a benign dermal melanocytic nevus. It typically presents as blue-gray Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10103-020-03125-9) contains supplementary material, which is available to authorized users. * Natalie M. Williams [email protected] 1
Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1150 NW 14th Street, Miami, FL 33136, USA
2
University of Miami Miller School of Medicine, Miami, FL, USA
3
Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA
4
Department of Dermatology and Cutaneous Surgery, College of Medicine, Qassim University, Buraydah, Saudi Arabia
hyperpigmented macules and patches on the face, generally distributed along the ophthalmic and maxillary divisions of the trigeminal nerve. The majority of cases affect unilateral facial regions such as the forehead, zygoma, and periorbital areas, with only 5–10% of lesions demonstrating bilateral involvement [1]. The condition is m
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