Efficacy and safety of adrenergic beta-antagonist combined with lasers in the treatment of infantile hemangiomas: a meta
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REVIEW ARTICLE
Efficacy and safety of adrenergic beta‑antagonist combined with lasers in the treatment of infantile hemangiomas: a meta‑analysis Xingfan Chen1 · Yu Guo1 · Pu Wang1 · Fengzhen Qiu1 · Yuming Sun1 · Qingmei Shi2 · Yuyan Deng1 · Chengjun Hu1 · Shaorong Lei1 Accepted: 1 July 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract To investigate the efficacy and safety of combined therapy with adrenergic beta-antagonist and lasers in infantile hemangiomas (IH). A search of Pubmed, Cochrane, Embase, Wanfang Date, CNKI (China National Knowledge Infrastructure) and CBM (China Biology Medicine) databases was conducted to identify studies that examined response to combined therapy with adrenergic beta-antagonist and laser in IH patients. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) in random-effects or fixed-effects models were calculated with Review Manger 5.3. Efficacy of combined therapy with oral propranolol and lasers was significantly better than that of propranolol (OR 5.79, 95% CI 2.52–13.31, P
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