Comparison of local sine wave modelling with harmonic phase analysis for the assessment of circumferential myocardial st
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Comparison of local sine wave modelling with harmonic phase analysis for the assessment of circumferential myocardial strain from tagged cardiovascular magnetic resonance images Christopher A Miller1,2*, Alexander Borg1, David Clark3, Christopher D Steadman4, Gerry P McCann4, Patrick Clarysse5, Pierre Croisille5,6, Matthias Schmitt1,2 From 15th Annual SCMR Scientific Sessions Orlando, FL, USA. 2-5 February 2012 Background Assessment of regional ventricular deformation is more sensitive than ejection fraction (EF) for detecting myocardial dysfunction. We sought to compare a local sinewave modelling (SinMod) method with the more established harmonic phase analysis (HARP) technique, for assessment of Lagrangian left ventricular (LV) peak systolic circumferential strain (εcc) from tagged cardiovascular magnetic resonance images, in patients with cardiomyopathies and healthy volunteers. The variability and rapidity of each technique, and the effect of contrast, were also assessed. Methods Sixty participants (15 each with hypertrophic, dilated or ischaemic cardiomyopathy and 15 healthy controls) with a wide range of LV ejection fraction (14-78%) underwent spatial modulation of magnetization tagging of a mid-ventricular short-axis slice at 1.5 Tesla. Global and segmental peak transmural εcc were measured using HARP and SinMod. Repeated measurements were performed on 15 randomly selected scans (25%) in order to assess observer variability. Tagged images were acquired pre- and post-contrast in 10 additional patients in order to assess the effect of contrast. Results There was a high level of agreement between HARP and SinMod for global εcc (mean difference -0.02, 95% limits 1 University Hospital of South Manchester, Manchester, UK Full list of author information is available at the end of the article
of agreement -6.46 to 6.43%, Figure 1). Agreement was much lower for segmental εcc, ranging from poor in lateral segments to modest in inferoseptal segments. Both methods showed excellent inter- and intraobserver agreement for global εcc (intraclass correlation coefficient>0.75). Inter- and intraobserver agreement for segmental εcc were also excellent with SinMod, and were significantly better than with HARP (p
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