The evaluation of left ventricular dyssynchronization in patients with hypertension by phase analysis of myocardial perf
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ORIGINAL ARTICLE
The evaluation of left ventricular dyssynchronization in patients with hypertension by phase analysis of myocardial perfusiongated SPECT Semra Ozdemir • Bahadır Kırılmaz • Ahmet Barutc¸u • Yusuf Ziya Tan • Fatmanur C ¸ elik Semra Akgoz
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Received: 19 September 2014 / Accepted: 19 November 2014 Ó The Japanese Society of Nuclear Medicine 2014
Abstract Purpose Hypertension is one of the most important risk factors for cardiovascular disease. However, hypertension may also result in left ventricular dyssynchrony (LVD) which is characterized by delayed activation of certain ventricular segments leading to uncoordinated contraction. The aim of this study was to evaluate the LVD measured by phase analysis of gated single-photon emission computed tomography (SPECT) imaging in patients with hypertension. Methods We retrospectively reviewed the records of the patients who have referred to our institution for myocardial perfusion imaging (MPI) with a diagnosis of cardiovascular disease. In this study, total of 196 patients (127 females and 69 males, with a mean age of 59.62 ± 10.27 years) with and without hypertension (123 and 73, respectively) were
included. Phase analysis parameters were compared in patients with and without hypertension which are derived using Emory Cardiac Toolbox. Among these 196 patients, 72 had echocardiography results. The findings of echocardiographic and phase analysis were also compared. Student’s t test, Kruskal–Wallis, Mann–Whitney U test and Spearman correlation test were used to compare the results. Results There were statistically significant differences in the phase standard deviation (p = 0.005) and histogram bandwidth (p \ 0.001) parameters of the phase analysis between the patients with and without hypertension groups, respectively. Furthermore, echocardiographic findings were significantly correlated with the result of the phase analysis. Conclusion This study suggested that routine use of phase analysis-gated SPECT imaging will be beneficial for the diagnosis of LVD.
S. Ozdemir (&) Y. Z. Tan F. C¸elik Department of Nuclear Medicine, Faculty of Medicine, Canakkale Onsekiz Mart University, 17100 Canakkale, Turkey e-mail: [email protected]
Keywords Left ventricular function Technetium-99 m Gated SPECT
Y. Z. Tan e-mail: [email protected]
Abbreviations ASH Asymmetrical septal hypertrophy DM Diabetes mellitus HT Hypertension LVD Left ventricular dyssynchrony LVEF Left ventricular ejection fraction LVH Left ventricular hypertrophy LVPW Left ventricular posterior wall IVS Interventricular septum MPI Myocardial perfusion imaging PHB Phase histogram bandwidth PSD Phase standard deviation SDS Summed difference score SMS Summed motion score
F. C¸elik e-mail: [email protected] B. Kırılmaz A. Barutc¸u Department of Cardiology, Faculty of Medicine, Canakkale Onsekiz Mart University, 17100 Canakkale, Turkey e-mail: [email protected] A. Barutc¸u e-mail: [email protected] S. Akgoz Department of Biostatistics, Faculty of Medicine, Canakkale Onsekiz M
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