Comparison of metastasis between early-onset and late-onset gastric signet ring cell carcinoma
- PDF / 1,357,403 Bytes
- 12 Pages / 595.276 x 790.866 pts Page_size
- 87 Downloads / 184 Views
Open Access
RESEARCH ARTICLE
Comparison of metastasis between early‑onset and late‑onset gastric signet ring cell carcinoma Qiang‑Ping Zhou1†, Yong‑Hua Ge2† and Cheng‑Yuan Liu1*
Abstract Background: There is little knowledge to date about the distant metastasis of early-onset gastric signet ring cell car‑ cinoma (SRCC) or the difference in metastasis based on age. Therefore, we conducted a comprehensive retrospective study using the Surveillance, Epidemiology, and End Results (SEER) database and data from our hospital. Methods: Patients were collected from the SEER database and our hospital. Univariate and multivariate logistic regression analyses and propensity score matching (PSM) were used to identify risk factors for metastasis. K-M survival curves were generated to analyse patient survival. Results: In total, we retrieved 2052 EOGC patients diagnosed with SRCC from the SEER database and included 403 patients from our hospital. K-M survival curves showed that late-onset SRCC patients had worse survival than earlyonset patients but that late-onset SRCC patients were less likely to have distant metastasis, as validated by SEER data (OR = 0.462, 95%CI, 0.272–0.787; P = 0.004) and our data (OR = 0.301, 95%CI, 0.135–0.672; P = 0.003). Multivariate logistic regression and PSM analysis revealed that age of 45 or younger was an independent risk factor for distant metastasis. Conclusion: Our study showed that distant metastasis was more common in early-onset SRCC than in late-onset SRCC. However, further studies are needed to explore the potential aetiologic basis for this disparity. Keywords: Early-onset gastric cancer, Signet ring cell carcinoma, Distant metastasis, SEER Background Gastric cancer (GC) is one of the most common tumours among all kinds of malignant carcinomas worldwide, with GC-associated death ranking fourth [1]. Currently, there are several classification systems for GC, including the Lauren classification and WHO classification. The Lauren classification divides GC into intestinal and diffuse types according to histological subtype; the WHO classification describes GC as four types, including signet ring *Correspondence: [email protected] † Qiang-Ping Zhou, Yong-Hua Ge have contributed equally to this work 1 Department of Emergency Surgery, The First Affiliated Hospital of Nanchang University, 17 Yongwaizheng Street, Nanchang 330006, Jiangxi, China Full list of author information is available at the end of the article
cell carcinoma (SRCC) and mucinous types [2, 3]. SRCC is defined as a histological type GC in which tumour cells are composed of many mucins (> 50% size of cell) and the nucleus is squeezed into the ridge of cell. SRCC belongs to diffuse-type GC and undifferentiated GC, predicting poorer prognosis compared to other types of GC [4]. Regarding the survival of SRCC, the 5-year disease-free survival (DFS) rate is 86.9% for stage I patients, 38.3% for stage II patients, and only 16.2% for stage III patients [5]. Compared to other types of GC, SRCC is considered an unfavourable pred
Data Loading...
