Comparison of vitreoretinal disorders in fellow eyes of lamellar macular holes versus epiretinal membrane foveoschisis
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RETINAL DISORDERS
Comparison of vitreoretinal disorders in fellow eyes of lamellar macular holes versus epiretinal membrane foveoschisis Ismael Chehaibou 1,2 & Niranjan Manoharan 1 & Andrea Govetto 3 & Anibal Andrés Francone 4 & David Sarraf 1 & Jean-Pierre Hubschman 1 Received: 21 April 2020 / Revised: 21 August 2020 / Accepted: 18 September 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose To evaluate and compare the rate and characteristics of vitreoretinal disorders in fellow eyes of lamellar macular holes (LMH) versus epiretinal membrane foveoschisis (ERMF). Methods Included patients in this retrospective study were divided into two groups based on spectral-domain optical coherence tomography (SD-OCT) features of their primary eye: LMH (group A) and ERMF (group B). Results Ninety-four patients were enrolled: 59 (62.8%) in group A and 35 (37.2%) in group B. Fellow eyes in group A had a higher rate of retinal detachment (8/59 [13.6%] vs. 0/35 [0%], P = 0.024), and full-thickness macular hole (FTMH) (11/59 [18.6%] vs. 2/35 [5.7%], P = 0.079), compared with fellow eyes in group B. In group A, 4/59 patients (6.8%) showed a bilateral LMH while none from group B had a LMH in their fellow eye (0/35 [0%]), P = 0.293. Additionally, epiretinal proliferation was noted in 30/59 (50.8%) fellow eyes in group A versus 3/35 (8.6%) fellow eyes in group B, P < 0.001. Longitudinal data were available for 80/94 patients. Over a mean follow-up of 37.4 ± 29.9 months, 1/48 (2.1%) fellow eyes from group A developed a FTMH and 2/48 (4.2%) developed a LMH, while no FTMH or LMH occurred in fellow eyes of group B. Conclusions Fellow eyes of LMH showed a high rate of macular and peripheral vitreoretinal disorders. In addition, epiretinal proliferation was detected in a higher number of fellow eyes of LMH versus ERMF. These findings suggest a bilateral process in eyes of patients with LMH. Keywords Epiretinal membrane foveoschisis . Epiretinal proliferation . Lamellar macular hole . Müller glial cells . Spectral-domain optical coherence tomography
Introduction Lamellar macular hole (LMH) is a macular lesion characterized by a partial thickness foveal defect but its true definition is debated and its pathogenesis still remains This article is part of a topical collection on Macular Holes * Jean-Pierre Hubschman [email protected] 1
Retina Division, Stein Eye Institute, University of California Los Angeles, 100 Stein Plaza, Los Angeles, CA, USA
2
Ophthalmology Department, Université de Paris, AP-HP, Hôpital Lariboisière, F-75010 Paris, France
3
Ophthalmology Department, Fatebenefratelli-Oftalmico Hospital, ASST-Fatebenefratelli-Sacco, Milan, Italy
4
Centro Oftalmológico Charles, Buenos Aires, Argentina
poorly understood. The study and classification of LMH have been hampered by the lack of universal consensus on a definition, which has resulted in the conflation of several different macular diseases over the past several years [1–3]. Various propositions have been made regarding the pathophysio
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