Computational Intelligence Methods for Bioinformatics and Biostatistics

This book constitutes the thoroughly refereed post-conference proceedings of the Fifth International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2008, held in Vietri sul Mare, Italy, in October 2008. The 23 rev

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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong

Subseries of Lecture Notes in Computer Science

Francesco Masulli Roberto Tagliaferri Gennady M. Verkhivker (Eds.)

Computational Intelligence Methods for Bioinformatics and Biostatistics 5th International Meeting, CIBB 2008 Vietri sul Mare, Italy, October 3-4, 2008 Revised Selected Papers

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Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Francesco Masulli Università di Genova Dipartimento di Informatica e Scienze dell’Informazione (DISI) Via Dodecaneso 35, 16146 Genova, Italy E-mail: [email protected] Roberto Tagliaferri Università di Salerno Dipartimento di Matematica ed Informatica (DMI) Via Ponte don Melillo, 84084 Fisciano (SA), Italy E-mail: [email protected] Gennady M. Verkhivker The University of Kansas School of Pharmacy, Department of Pharmaceutical Chemistry 2095 Constant Avenue, Lawrence, KS 66047, USA E-mail: [email protected]

Library of Congress Control Number: 2009929551

CR Subject Classification (1998): H.2.8, F.2.1, I.2, G.2.2, J.3, E.1 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13

0302-9743 3-642-02503-X Springer Berlin Heidelberg New York 978-3-642-02503-7 Springer Berlin Heidelberg New York

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. springer.com © Springer-Verlag Berlin Heidelberg 2009 Printed in Germany Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper SPIN: 12697106 06/3180 543210

Preface

This volume contains a selection of the best contributions delivered at the 5th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics (CIBB 2008) held at IIASS “E. R. Caianiello”, Vietri sul Mare, Salerno, Italy during October 3–4, 2008. The CIBB meeting series is organized by the Special Interest Group on Bioinformatics of the International Neural Network Society (INNS) to provide a forum open to researchers from different disciplines to present and discuss problems concerning computational techniques in bioinformatics, systems biology and medical informatics with a particular focus on neural networks, machine learning, fuzzy logic, and evolutionary computational metho