Computational Intelligence Methods for Bioinformatics and Biostatistics

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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong

Subseries of Lecture Notes in Computer Science

Francesco Masulli Leif E. Peterson Roberto Tagliaferri (Eds.)

Computational Intelligence Methods for Bioinformatics and Biostatistics 6th International Meeting, CIBB 2009 Genoa, Italy, October 15-17, 2009 Revised Selected Papers

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Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Francesco Masulli Università di Genova, DISI, Via Dodecaneso 35, 16146 Genoa, Italy E-mail: [email protected] Leif E. Peterson Cornell University, Weill Cornell Medical College, TMHRI 6565 Fannin, Suite MGJ6-031, Houston, Texas 77030, USA E-mail: [email protected] Roberto Tagliaferri Università di Salerno, DMI, Via Ponte don Melillo 84084 Fisciano (Sa), Italy E-mail: [email protected]

Library of Congress Control Number: 2010930710

CR Subject Classification (1998): F.1, J.3, I.4, I.2, I.5, F.2 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13

0302-9743 3-642-14570-1 Springer Berlin Heidelberg New York 978-3-642-14570-4 Springer Berlin Heidelberg New York

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. springer.com © Springer-Verlag Berlin Heidelberg 2010 Printed in Germany Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper 06/3180

Preface

This volume contains a selection of the best contributions delivered at the 6th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics (CIBB 2009) held at Oratorio San Filippo Neri in Genoa (Italy) during October 15–17, 2009. The CIBB meeting series is organized by the Special Interest Group on Bioinformatics of the International Neural Network Society (INNS) to provide a forum open to researchers from different disciplines to present and discuss problems concerning computational techniques in bioinformatics, systems biology and medical informatics with a particular focus on neural networks, machine learning, fuzzy logic, and evolutionary computational methods. From 2004 to 2007, CIBB meetings were held with an increasing number of participants in the format of a special session of bigger conferences, namely, WIRN 2004 i