Computed Tomography Perfusion Core Infarct Measurement Compared to Diffusion-Weighted Magnetic Resonance Imaging in Pati
- PDF / 2,186,186 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 64 Downloads / 247 Views
IMAGING
Computed Tomography Perfusion Core Infarct Measurement Compared to Diffusion-Weighted Magnetic Resonance Imaging in Patients with Revascularization of Anterior Circulation, Large Artery Occlusion Ischemic Stroke Rahul R. Karamchandani 1 & Jeremy B. Rhoten 2 & Dale Strong 3 & Brenda Chang 3 & Gary Defilipp 4 & Joe Bernard 5 & Jonathan D. Clemente 4 & Eric Wang 4 & Ross Bellavia 4 & William Stetler 5 & Jeffrey Bodle 1 & Andrew U. Hines 4 & Andrew W. Asimos 6 Accepted: 18 November 2020 / Published online: 24 November 2020 # Springer Nature Switzerland AG 2020
Abstract Relative cerebral blood flow (CBF) < 30% has been identified as a predictor of infarct core on computed tomography perfusion (CTP). We investigated the relationship between CTP-predicted infarct core and diffusion-weighted imaging magnetic resonance imaging (DWI MRI). We conducted a retrospective analysis comparing infarct core (CBF < 30%; RAPID iSchemaView) and post-revascularization DWI MRI (ADC < 620 cc; RAPID iSchemaView) in patients with internal carotid artery (ICA) or proximal middle cerebral artery (MCA) stroke between November 2016 and May 2019. Included subjects had a modified Thrombolysis in Cerebral Infarction (mTICI) score of 2b or better and presented within 24 h of last known well (LKW) time. Two hundred one cases were identified. Mean duration from LKW time to CTP and MRI was 4.3 and 28.6 h, respectively. Median ischemic core volume was 8 cc, and median MRI infarct volume was 17 cc. CTP core volume showed fair correlation with MRI infarct volume (r = 0.294, p < 0.0001). There was a stronger association between CBF < 30% and DWI MRI in subjects presenting beyond 6 h (r = 0.359, p = 0.011). In a multivariate analysis, greater volumetric difference was associated with younger age (p = 0.001), longer duration from LKW time to revascularization time (p < 0.020), and longer CTP to revascularization time (p < 0.0001). Reduced relative CBF < 30% is a fair measure of infarct size within 24 h of anterior circulation, large artery occlusion (LAO) stroke when adequate reperfusion is achieved. Keywords CTP . MRI . Stroke . Thrombectomy . Revascularization
This article is part of the Topical Collection on Imaging * Rahul R. Karamchandani [email protected] 1
Department of Neurology, Atrium Health, Charlotte, NC, United States
2
Atrium Health, Charlotte, NC, USA
3
Information and Analytics Services, Atrium Health, Charlotte, NC, USA
4
Charlotte Radiology, Atrium Health, Charlotte, NC, USA
5
Carolina Neurosurgery and Spine Associates, Atrium Health, Charlotte, NC, USA
6
Department of Emergency Medicine, Atrium Health, Charlotte, NC, USA
Introduction Randomized clinical trials have demonstrated the efficacy of endovascular therapy (EVT) for patients with large artery occlusion (LAO) acute ischemic stroke [1–3]. Two early window stroke intervention trials that established the benefit of EVT excluded patients with large core infarct sizes from enrollment [4, 5]. More recently, the Endovascular Therapy Following Imaging Evalua
Data Loading...