Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models
Flow of ions through voltage gated channels can be represented theoretically using stochastic differential equations where the gating mechanism is represented by a Markov model. The flow through a channel can be manipulated using various drugs, and the ef
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Aslak Tveito · Glenn T. Lines
Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models
Editorial Board T. J.Barth M.Griebel D.E.Keyes R.M.Nieminen D.Roose T.Schlick
Lecture Notes in Computational Science and Engineering
Editors: Timothy J. Barth Michael Griebel David E. Keyes Risto M. Nieminen Dirk Roose Tamar Schlick
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More information about this series at http://www.springer.com/series/3527
Aslak Tveito • Glenn T. Lines
Computing Characterizations of Drugs for Ion Channels and Receptors Using Markov Models
Aslak Tveito Center for Biomedical Computing Simula Research Laboratory Lysaker, Norway
Glenn T. Lines Center for Biomedical Computing Simula Research Laboratory Lysaker, Norway
ISSN 1439-7358 ISSN 2197-7100 (electronic) Lecture Notes in Computational Science and Engineering ISBN 978-3-319-30029-0 ISBN 978-3-319-30030-6 (eBook) DOI 10.1007/978-3-319-30030-6 Library of Congress Control Number: 2016937425 Mathematics Subject Classification (2010): 34F05, 60J20, 60J28, 62M05, 80A30, 92C45 © The Editor(s) (if applicable) and The Author(s) 2016. This book is published open access. Open Access This book is distributed under the terms of the Creative Commons AttributionNonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, duplication, adaptation, distribution, and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, a link is provided to the Creative Commons license, and any changes made are indicated. The images or other third party material in this book are included in the work’s Creative Commons license, unless indicated otherwise in the credit line; if such material is not included in the work’s Creative Commons license and the respective action is not permitted by statutory regulation, users will need to obtain permission from the license holder to duplicate, adapt, or reproduce the material. This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or f
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