COMT-Val158Met polymorphism modulates antipsychotic effects on auditory verbal hallucinations and temporal lobe gray mat
- PDF / 727,573 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 34 Downloads / 231 Views
ORIGINAL RESEARCH
COMT-Val158Met polymorphism modulates antipsychotic effects on auditory verbal hallucinations and temporal lobe gray matter volumes in healthy individuals—symptom relief accompanied by worrisome volume reductions Chuanjun Zhuo 1,2,3,4,5,6 & Langlang Cheng 5 & Gongying Li 2 & Yong Xu 4,6 & Rixing Jing 7,8 & Shen Li 3 & Li Zhang 9 & Xiaodong Lin 5 & Chunhua Zhou 10
# The Author(s) 2019
Abstract Investigation of auditory verbal hallucinations (AVHs) in schizophrenics is complicated by psychiatric symptoms. Investigating healthy individuals with AVHs (H-AVHs) can obviate such confounding factors. The objective of this study was to explore the effects of antipsychotic treatment on AVHs and gray matter volumes (GMVs) in H-AVH subjects and whether such are effects are influenced by COMT-Val158Met genotype. Magnetic resonance imaging (MRI) and genotyping studies were completed for 42 H-AVH subjects and 42 well-matched healthy controls (HCs). COMT-Met/Met homozygotes (158th codon) were identified as COMT-Met genotype; COMT-Met/Val heterozygotes and COMT-Val/Val homozygotes were identified as COMT-Val genotype. Data were compared across groups (H-AVH vs. HC, and between genotypes) with two-sample t-tests. The H-AVH COMT-Met group showed a stronger response to antipsychotic treatment than the H-AVH COMT-Val group (p < 0.001). Both H-AVH genotype groups exhibited temporal lobe GMV reductions after treatment, and relative to their respective genotype-matched HC groups. Antipsychotic treatment effects in H-AVH subjects were influenced by COMT-Val158Met genotype and associated with widespread GMV reductions. These findings provide clues for further exploration of treatment targets for AVHs. Treatment associated GMV reductions, however, raise concerns about use of antipsychotics in H-AVH subjects. Keywords Auditory verbal hallucination . Anti-psychotic . Hi-AVHs . COMT . MRI
Chuanjun Zhuo, Langlang Cheng and Gongying Li contributed equally to this work. * Chuanjun Zhuo [email protected]; [email protected]
4
Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China
* Xiaodong Lin [email protected]
5
Department of Psychiatry, Wenzhou Seventh People’s Hospital, Wenzhou 325000, China
* Chunhua Zhou [email protected]
6
Department of Psychiatry, Shanxi Medical University, Taiyuan 030000, China
7
Department of Pattern Recognition, China National Key Laboratory, Institute of Automation, Chinese Academy of Sciences, Beijing 100191, China
8
Department of Pattern Recognition, University of Chinese Academy of Sciences, Beijing 100191, China
Department of Psychiatry, Institute of Mental Healthy, Genetic Lab, Jining Medical University, Jining 272191, China
9
GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, Guangdong Province, China
Department of Psychiatry, College of Basic Medical Research, Tianjin Medical University, Tianjin 300000, China
10
Department of Pharmacy, The First Hospital of Hebei Medical
Data Loading...