KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly
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ORIGINAL RESEARCH
KIBRA polymorphism modulates gray matter volume to influence cognitive ability in the elderly Rui Li 1,2 & Wenyu Wan 1,2 & Juan Li 1,2,3,4
# Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Genetic variation in the kidney and brain expressed protein (KIBRA) rs17070145 gene has been linked to episodic memory and cognitive aging; yet, the neural mechanism underlying this association remains to be fully understood. Using the magnetic resonance imaging (MRI) technique, this study investigated the effect of KIBRA polymorphism on gray matter volume in 37 healthy, Chinese adults from the older population. Voxel-based morphometry (VBM) analysis revealed that KIBRA gene selectivity influences the prefrontal cortex and the parahippocampal cortex. The gray matter volume (GMV) in these structures is significantly lower in KIBRA C-allele carriers than in TT carriers. Moreover, multi-voxel pattern correlation analysis revealed that decreased prefrontal GMV could in turn affect individual cognitive function in C-allele carriers; whereas, TT individuals utilized more integrated gray matter volume in whole-brain voxels to achieve relatively better cognitive function. Overall, the findings suggest that the KIBRA rs17070145 polymorphism modulates gray matter volume, which in turn further influences cognitive function in the elderly. Keywords KIBRA . Gray matter volume . VBM . Aging . Prefrontal
Introduction The KIBRA (kidney and brain expressed protein) rs17070145 gene was identified to be associated with episodic memory in the first, human genome-wide screen of memory-related gene variants (Papassotiropoulos et al. 2006). Most studies of KIBRA polymorphism and memory have found that KIBRA rs17070145 T-allele carriers perform better than C-allele homozygotes (Papassotiropoulos et al. 2006; Muse et al. 2014; Milnik et al. 2012; Kauppi et al. 2011); however, non-significant or contradicting results have also been reported (Nacmias et al.
* Juan Li [email protected] 1
Center on Aging Psychology, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Chaoyang District, Beijing 100101, China
2
Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
3
Magnetic Resonance Imaging Research Center, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
4
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
2008; Wersching et al. 2011). The effect of the KIBRA gene on memory has been previously demonstrated to increase from early to late adulthood period; additionally, KIBRA is increasingly thought to play an important role in cognitive aging (Lindenberger et al. 2008; Papenberg et al. 2015). KIBRA is mainly expressed in the hippocampus and association areas in the human brain (Papassotiropoulos et al. 2006). Some studies have used neuroimaging methods including magnetic resonance imaging (MRI) to investigate the neural mechan
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