Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study
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(2020) 21:141
The Journal of Headache and Pain
RESEARCH ARTICLE
Open Access
Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study Zhengjie Li1,2†, Jun Zhou1†, Lei Lan1, Shirui Cheng1, Ruirui Sun1, Qiyong Gong3, Max Wintermark2, Fang Zeng1* and Fanrong Liang1*
Abstract Objectives: To explore the possible concurrent brain functional and structural alterations in patients with migraine without aura (MwoA) patients compared to healthy subjects (HS). Methods: Seventy-two MwoA patients and forty-six HS were recruited. 3D-T1 and resting state fMRI data were collected during the interictal period for MwoA and HS. Voxel-based morphometry (VBM) for structure analysis and regional homogeneity (Reho) for fMRI analysis were applied. The VBM and Reho maps were overlapped to determine a possible brain region with concurrent functional and structural alteration in MwoA patients. Further analysis of resting state functional connectivity (FC) alteration was applied with this brain region as the seed. Results: Compared with HS, MwoA patients showed decreased volume in the bilateral superior and inferior colliculus, periaqueductal gray matter (PAG), locus ceruleus, median raphe nuclei (MRN) and dorsal pons medulla junction. MwoA patients showed decreased Reho values in the middle occipital gyrus and inferior occipital gyrus, and increased Reho values in the MRN. Only a region in the MRN showed both structural and functional alteration in MwoA patients. Pearson correlation analysis showed that there was no association between volume or Reho values of the MRN and headache frequency, headache intensity, disease duration, self-rating anxiety scale or selfrating depression scale in MwoA patients. Resting state functional connectivity (FC) with the MRN as the seed showed that MwoA patients had increased FC between the MRN and PAG. Conclusions: MRN are involved in the pathophysiology of migraine during the interictal period. This study may help to better understand the migraine symptoms. Trial registration: NCT01152632. Registered 27 June 2010. Keywords: Migraine, Functional magnetic resonance imaging (fMRI), Regional homogeneity (Reho), Voxel-based Morphometry (VBM), Functional connectivity (FC), Median raphe nuclei (MRN)
* Correspondence: [email protected]; [email protected] † Zhengjie Li and Jun Zhou contributed equally to this work. 1 Acupuncture & Tuina School / The 3rd Teaching Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu 610036, Sichuan, China Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are
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