Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine
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ORIGINAL ARTICLE
Confirmation of maximal hyperemia by the incremental dose of intracoronary papaverine Masafumi Nakayama1,2 · Nobuhiro Tanaka3 · Jun Yamashita1 · Kiyotaka Iwasaki2,4 Received: 4 October 2019 / Accepted: 8 January 2020 © Japanese Association of Cardiovascular Intervention and Therapeutics 2020
Abstract We investigated the effect of the papaverine dose increment method to confirm maximal hyperemia for fractional flow reserve (FFR) measurements. We evaluated 115 consecutive patients involving 200 lesions. FFR was measured after intracoronary papaverine injection into the left (12 mg) and right (8 mg) coronary arteries as standard doses. Except for 2 patients who had ventricular tachyarrythmia (VTA), we administered a higher papaverine dose (2 mg added to the standard dose). We compared the FFR values after using different papaverine doses. VTA incidence and electrocardiogram parameters were compared according to the papaverine doses used. The QTU interval and corrected QTU were significantly prolonged after using a higher dose compared with a standard dose. VTA occurred in one patient (0.9%) at the higher dose. There was no significant difference with a strong correlation between the FFR values in the 2 doses (r = 0.963, P
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