Congenital Cytomegalovirus Infection Epidemiology, Diagnosis, Therap
Congenital cytomegalovirus (CMV) infection is the most common intrauterine transmitted viral infection, with a tremendous impact on fetuses and newborns. In this book the history of this disease, its pathophysiological background, epidemiology and symptom
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Gabriele Halwachs-Baumann Editor
Congenital Cytomegalovirus Infection Epidemiology, Diagnosis, Therapy
SpringerWienNewYork
Prim. Univ.-Prof. Dr. Gabriele Halwachs-Baumann, MSc, MBA Department for Laboratory Medicine, Regional Hospital Steyr, Steyr, Austria
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machines or similar means, and storage in data banks. Product Liability: The publisher can give no guarantee for all the information contained in this book. This does also refer to information about drug dosage and application thereof. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. © 2011 Springer-Verlag Wien Printed in Germany SpringerWienNewYork is part of Springer Science+Business Media springer.at Typesetting: le-tex publishing services GmbH, 04229 Leipzig, Germany Printing: Strauss GmbH, 69509 Mörlenbach, Germany Printed on acid-free and chlorine-free bleached paper SPIN: 12759590 With 15 (partly coloured) Figures Library of Congress Control Number: 2010940097
ISBN 978-3-7091-0207-7 SpringerWienNewYork
Dedicated to all those people who have been congenitally infected with CMV because of a lack of awareness, a lack of diagnostic methods and a lack of therapeutic possibilities.
Preface
Congenital cytomegalovirus (CMV) infection is the most common intrauterine transmitted viral infection, and has a tremendous impact on fetuses and newborns. In this book the history of this disease, its pathophysiological background, epidemiology and symptoms, as well as diagnostic and therapeutic strategies, will be discussed. Starting with an outline of the historical background (Chapter 1 – “Long known. Long ignored”), Chapters 2–5 are dedicated to the topics of virus–host interaction for defence and transmission, epidemiology (and the influence of socioeconomic differences), diagnosis and clinical outcome (written by Th. W. Orlikowsky) respectively. Strategies for disease prevention and therapy are delineated in Chapter 6. As economic aspects are gaining more and more importance in health politics, Chapter 7 (written by E. Walter, Ch. Brennig and V. Schöllbauer), is dedicated to this issue in the context of congenital CMV infection. This work is based on the latest scientific findings and written in an understandable manner, allowing persons not working in the field of congenital CMV to profit from it as well. Thus, the content is of interest for medical doctors, nurses, midwives, economists, but also for a wider audience, i. e. to all who want to inform themselves about this topic. In this sense, it should not only help towards a better und
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