Relationship between prognosis of biliary atresia and infection of cytomegalovirus
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Relationship between prognosis of biliary atresia and infection of cytomegalovirus Chun Shen, Shan Zheng, Wei Wang, Xian-Min Xiao Shanghai, China
Methods: From January 2002 to March 2004, 27 patients who had undergone Kasai's procedure because of biliary atresia were investigated for cytomegalovirus -IgG, IgM and pp65, and their mothers were also examined for confirmation of cytomegalovirus infection. The patients were divided into three groups: infection free group, cytomegalovirus positive group and cytomegalovirus infection group. The rate of jaundice disappearance and the incidence of reflux cholangitis were analyzed statistically. The histopathological changes of the liver were also analyzed. Results: The positive expression of cytomegalovirus -IgM and cytomegalovirus-pp65 in the patients was higher than that in their mothers (48% versus 14.81% and 37% versus 3.78%, respectively). Compared with the other two groups (80% in the infection free group, and 82% in the cytomegalovirus positive group), the rate of jaundice disappearance after operation in the cytomegalovirus infection group (36%) was significantly lower (P
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