Conjugated hydrophobic and hydrophilic blocks through a drug moiety as a leading macromolecular system for sustainable d
- PDF / 2,092,095 Bytes
- 13 Pages / 595.276 x 790.866 pts Page_size
- 51 Downloads / 167 Views
ORIGINAL PAPER
Conjugated hydrophobic and hydrophilic blocks through a drug moiety as a leading macromolecular system for sustainable drug delivery S. Kailash1 · B. Meenarathi1 · V. Parthasarathy2 · R. Anbarasan3 Received: 11 July 2020 / Accepted: 22 September 2020 © The Polymer Society, Taipei 2020
Abstract Ring-opening polymerization (ROP) of ε-caprolactone (CL) had been performed at 160 °C in the presence of drug molecules such as penicillin g (Pen), streptavidin (Strep) and terramicin (Ter) as a lone chemical initiator using the catalyst, stannous octoate (SO) under N2 atmosphere. The prepared drug bridged poly (ε-caprolactone) (PCL) was further copolymerized with tetrahydrofuran (THF) and the diblock copolymers were examined using the various analytical tools (FT-IR, DSC, TGA, SEM, FE-SEM, EDX, UV-visible and GPC). The functionalities of the drug bridged diblock copolymers were concluded by FT-IR spectra. The formation of the diblock copolymer was further understood from the increase in M w. The drug release activity of homo and diblock copolymer had been tested with the drug release model and mechanism. The mechanical properties are also studied. Keywords Drugs · Diblock copolymer · DSC · FE-SEM · TGA · Drug release
Introduction Recently, the pharmaceutical chemists and polymer scientists are combined and actively working for sustainable drug release from the polymer backbone. The sudden release of all the drug molecules from the polymer backbone leads to overdose sometimes that causes side effects to the patients. The reason behind the drug release is a hydrogen bonding mechanism. Once there are any changes in the temperature or pH, the hydrogen bond between the polymer backbone and drug molecule breaks, and all the drug molecules are delivered at a time. In order to outwit this problem, a sustainable drug release is required. Before having a look into the sustainable drug release (SDR), a study is made on the * R. Anbarasan [email protected] 1
Department of Polymer Technology, Kamaraj College of Engineering and Technology, Madurai 625701, Tamil Nadu, India
2
Department of Physics, Hindustan Institute of Technology and Science, Padur, Chennai 603103, Tamil Nadu, India
3
Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan
conventional drug release. In 2011, Ogaji et al [1]. reviewed the conventional drug release study using bio-polymeric backbone. In 2014, smart polymer-based drug delivery was reported by Priya and co-workers [2]. In 2017, the application of polymers in drug delivery was thoroughly explained by Oh. [3] Drug delivery of theophylline was made by polymer blends [4]. A biocompatible poly(ester amide) was used for drug release study [5]. Like this, other polymers such as poly (glycolic acid) [6], poly(organophosphazenes) [7], PEG-co-PAA [8], PCL [9] and PEG-PCL [10] were used for drug delivery application. To obtain a sustainable drug delivery, again polymers are used as drug carriers, for eg. Methacrylic acid-co-ethyl acrylate copolymer
Data Loading...
