Considerations in Developing Reporter Gene Bioassays for Biologics
The establishment of a robust and reproducible functional bioassay that reliably measures drug potency while ascertaining its mode of action is essential in biologic drug development. Here we describe a simple bioluminescent reporter gene bioassay for ass
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Seng-Lai Tan Editor
ImmunoOncology Cellular and Translational Approaches
METHODS
IN PHARMACOLOGY AND TOXICOLOGY
Series Editor Y. James Kang Department of Pharmacology and Toxicology University of Louisville Louisville, KY, USA
For further volumes: http://www.springer.com/series/7653
Methods in Pharmacology and Toxicology publishes cutting-edge techniques, including methods, protocols, and other hands-on guidance and context, in all areas of pharmacological and toxicological research. Each book in the series offers time-tested laboratory protocols and expert navigation necessary to aid toxicologists and pharmaceutical scientists in laboratory testing and beyond. With an emphasis on details and practicality, Methods in Pharmacology and Toxicology focuses on topics with wide-ranging implications on human health in order to provide investigators with highly useful compendiums of key strategies and approaches to successful research in their respective areas of study and practice.
Immuno-Oncology Cellular and Translational Approaches
Edited by
Seng-Lai Tan Elstar Therapeutics, Cambridge, MA, USA
Editor Seng-Lai Tan Elstar Therapeutics Cambridge, MA, USA
ISSN 1557-2153 ISSN 1940-6053 (electronic) Methods in Pharmacology and Toxicology ISBN 978-1-0716-0170-9 ISBN 978-1-0716-0171-6 (eBook) https://doi.org/10.1007/978-1-0716-0171-6 © Springer Science+Business Media, LLC, part of Springer Nature 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Cancer would be quite common in long-lived organisms if not for the protective effects of immunity Ehrlich P, Ned Tijdschr Geneeskd 5, 273 (1909)
The first wave of cancer immunotherapeutics, including
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