Reporter Gene Imaging Methods and Protocols
This volume provides an introduction for the scientist who is new to the field of molecular imaging, as well as detailed methods for experts in other areas of molecular imaging. Chapters detail the advantages and limitations of combining fluorescent, biol
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Purnima Dubey Editor
Reporter Gene Imaging Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Reporter Gene Imaging Methods and Protocols
Edited by
Purnima Dubey Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, USA
Editor Purnima Dubey Department of Microbial Infection and Immunity The Ohio State University Columbus, OH, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7858-8 ISBN 978-1-4939-7860-1 (eBook) https://doi.org/10.1007/978-1-4939-7860-1 Library of Congress Control Number: 2018942967 © Springer Science+Business Media, LLC, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Advances in the field of molecular imaging have provided biologists with tools to noninvasively follow fundamental biology processes with unprecedented ease and sensitivity. Noninvasive imaging techniques include radioactive, magnetic, and light-based methods to visualize cell movement, cell-cell communication, and gene expression. The strength of reporter gene-based molecular imaging lies in the ability to track both the movement and function of cell populations in living subjects. Furthermore, the use of more than one imaging modality provides complementary information. This volume begins with a discussion of the advantages and limitations of combining fluorescent, bioluminescent, and radioisotopic reporter genes into one construct. T
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